ArticleBritish journal of cancer2010
The attitudes of 1066 patients with cancer towards participation in randomised clinical trials.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Decision aids for people considering taking part in clinical trials.The Cochrane database of systematic reviews · 2015Pooled it
- Reasons for and against participation in studies of medicinal therapies for women with breast cancer: a debate.BMC medical research methodology · 2012Pooled it
- Recruiting women with ductal carcinoma in situ to a randomised controlled trial: lessons from the LORIS study.Trials · 2023Trial
- Study design factors influencing patients' willingness to participate in clinical research: a randomised vignette-based study.BMC medical research methodology · 2020Trial
- Improving decision making about clinical trial participation - a randomised controlled trial of a decision aid for women considering participation in the IBIS-II breast cancer prevention trial.British journal of cancer · 2014Trial
- Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Trial
- Assessing an intervention to improve clinical trial perceptions among predominately African-American communities in South Carolina.Progress in community health partnerships : research, education, and action · 2012Trial
- Progress and challenges in expanding access to clinical trials in pancreatic cancer.Communications medicine · 2026Review
- Attitudes and Willingness to Participate in Drug Clinical Trials Among Patients With Cancer: Multistage Qualitative Study.Journal of medical Internet research · 2026Article
- Methodology and predictive accuracy of the prospective preference assessment for randomized trial enrollment: A literature review.Osteoarthritis and cartilage open · 2025Review
- Data Sources for Clinical T1 Renal Masses and the Potential for Bias.Clinical genitourinary cancer · 2025Article
- Patient perspectives on participation in the Danish Breast Cancer Group Proton Trial: A qualitative research study.Technical innovations & patient support in radiation oncology · 2025Review
- Use of complementary therapies and supportive measures of patients with intracranial gliomas-a prospective evaluation in an outpatient clinic.Journal of neuro-oncology · 2024Article
- Comparison of clinical outcomes among cancer patients treated in and out of clinical trials.BMC cancer · 2023Observational
- Article
- Text Classification of Cancer Clinical Trial Eligibility Criteria.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Improving community participation in clinical trials in Ghana; factors to consider.Contemporary clinical trials communications · 2022Article
- Article
- The attitude of patients with progressive ataxias towards clinical trials.Orphanet journal of rare diseases · 2022Article
- Factors Influencing Public Knowledge and Willingness to Participate in Biomedical Research in Jordan: A National Survey.Patient preference and adherence · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundbarriers to randomised clinical trial (RCT) recruitment include failure to identify eligible patients, reluctance of staff to approach them and attitudes of some health-care professionals and patients. As part of a larger UK prospective study examining the communication and involvement in RCTs of 22 multidisciplinary teams in Wales, we also assessed the attitudes of patients they treat towards trials.
methodsout of 1146 patients attending outpatient departments who were approached, 1146 (93%) completed the seven-item Attitudes to Randomised Trials Questionnaire (ARTQ), probing their general attitudes towards medical research and likely participation in a hypothetical two-arm RCT.
resultsrandomisation initially deterred many patients from endorsing a willingness to participate. However, if information about the trial logic, voluntary nature and rights to withdraw were provided, together with further treatment details, 83% (886 out of 1066) would potentially participate. Other variables associated with a positive inclination towards participation included previous trial experience (P<0.01), male gender (P<0.01) and younger age, with patients > or =70 years less likely to consider trial entry (P<0.01).
conclusionthe majority of patients were receptive to RCT participation. Many of those initially disinclined because of randomisation would consider joining if given further details that form part of standard GCP consent guidelines. These data show the importance and need for clear communication and information to encourage RCT participation. Evidence-based training courses are available to assist with this.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.