ArticleMolecular systems biology2010
Chromatin regulators as capacitors of interspecies variations in gene expression.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Systematic genetic perturbation reveals principles underpinning robustness of the epigenetic regulatory network.Nucleic acids research · 2025Article
- Chromatin-based memory as a self-stabilizing influence on cell identity.Genome biology · 2024Review
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Mutational robustness and the role of buffer genes in evolvability.The EMBO journal · 2024Review
- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change.Nature communications · 2023Article
- Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness.Cell reports · 2022Article
- Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis.G3 (Bethesda, Md.) · 2022Article
- Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.BMC biology · 2020Article
- EvoChromo: towards a synthesis of chromatin biology and evolution.Development (Cambridge, England) · 2019Review
- Article
- Genome and transcriptome evolve separately in recently hybridizedCommunications biology · 2019Article
- FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators.Nucleic acids research · 2018Article
- The complex underpinnings of genetic background effects.Nature communications · 2018Article
- Determination of dosage compensation and comparison of gene expression in a triploid hybrid fish.BMC genomics · 2017Article
- A New Mechanism for Mendelian Dominance in Regulatory Genetic Pathways: Competitive Binding by Transcription Factors.Genetics · 2017Article
- Modifiers of the Genotype-Phenotype Map: Hsp90 and Beyond.PLoS biology · 2016Review
- Molecular mechanisms governing differential robustness of development and environmental responses in plants.Annals of botany · 2016Review
- Genetic assimilation: a review of its potential proximate causes and evolutionary consequences.Annals of botany · 2016Review
- Prediction of fine-tuned promoter activity from DNA sequence.F1000Research · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression varies widely between closely related species and strains, yet the genetic basis of most differences is still unknown. Several studies suggested that chromatin regulators have a key role in generating expression diversity, predicting a reduction in the interspecies differences on deletion of genes that influence chromatin structure or modifications. To examine this, we compared the genome-wide expression profiles of two closely related yeast species following the individual deletions of eight chromatin regulators and one transcription factor. In all cases, regulator deletions increased, rather than decreased, the expression differences between the species, revealing hidden genetic variability that was masked in the wild-type backgrounds. This effect was not observed for individual deletions of 11 enzymes involved in central metabolic pathways. The buffered variations were associated with trans differences, as revealed by allele-specific profiling of the interspecific hybrids. Our results support the idea that regulatory proteins serve as capacitors that buffer gene expression against hidden genetic variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.