ArticleOncogene2011
A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma.
Article in Oncogene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative transcriptome and miRNA analysis of skin pigmentation during embryonic development of Chinese soft-shelled turtle (Pelodiscus sinensis).BMC genomics · 2022Article
- Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome.Journal of pregnancy · 2022Review
- More than just acral melanoma: the controversies of defining the disease.The journal of pathology. Clinical research · 2021Review
- Estrogen Receptors and Melanoma: A Review.Cells · 2019Review
- The rs17084733 variant in theEpigenetics · 2019Article
- Cardiac c-Kit Biology Revealed by Inducible Transgenesis.Circulation research · 2018Article
- Emerging Biomarkers in Cutaneous Melanoma.Molecular diagnosis & therapy · 2018Review
- Article
- The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Effects of genetic variations on microRNA: target interactions.Nucleic acids research · 2014Article
- Aberrant regulation and function of microRNAs in cancer.Current biology : CB · 2014Review
- Article
- Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases.Cell cycle (Georgetown, Tex.) · 2014Article
- Control by a hair's breadth: the role of microRNAs in the skin.Cellular and molecular life sciences : CMLS · 2013Review
- MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy.Carcinogenesis · 2012Review
- Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes.PloS one · 2012Article
- MicroRNA signatures differentiate melanoma subtypes.Cell cycle (Georgetown, Tex.) · 2011Article
- MiR-146a in Immunity and Disease.Molecular biology international · 2011Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) are small ∼22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3' untranslated region (3' UTRs) of target gene messenger RNAs (mRNA). Recently, mutations have been identified in both miRNAs and target genes that disrupt regulatory relationships, contribute to oncogenesis and serve as biomarkers for cancer risk. KIT, an established oncogene with a multifaceted role in melanogenesis and melanoma pathogenesis, has recently been shown to be upregulated in some melanomas, and is also a target of the miRNA miR-221. Here, we describe a genetic variant in the 3' UTR of the KIT oncogene that correlates with a greater than fourfold increased risk of acral melanoma. This KIT variant results in a mismatch in the seed region of a miR-221 complementary site and reporter data suggests that this mismatch can result in increased expression of the KIT oncogene. Consistent with the hypothesis that this is a functional variant, KIT mRNA and protein levels are both increased in the majority of samples harboring the KIT variant. This work identifies a novel genetic marker for increased heritable risk of melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.