ArticleThe Journal of biological chemistry2011
WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.PLoS pathogens · 2023Article
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.Experimental & molecular medicine · 2023Review
- The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer.Cancer research communications · 2023Article
- The Role of WAVE2 Signaling in Cancer.Biomedicines · 2021Review
- WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge.Molecular biology of the cell · 2020Article
- Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.Journal of cell science · 2017Article
- Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.Cell reports · 2016Article
- Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.Oncogene · 2015Article
- Phosphoregulation of the WAVE regulatory complex and signal integration.Seminars in cell & developmental biology · 2013Review
- Article
- Cross-talk between calcium and protein kinase A in the regulation of cell migration.Current opinion in cell biology · 2011Review
- WASP family proteins: Molecular mechanisms and implications in human disease.European journal of cell biologyArticle
- Carbonic anhydrase IX: a hypoxia-controlled "catalyst" of cell migration.Cell adhesion & migrationArticle
- The WASP/WAVE Protein Family in Breast Cancer and Their Role in the Metastatic Cascade.Cancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PKA contributes to many physiological processes, including glucose homeostasis and cell migration. The substrate specificity of PKA is low compared with other kinases; thus, complex formation with A-kinase-anchoring proteins is important for the localization of PKA in specific subcellular regions and the phosphorylation of specific substrates. Here, we show that PKA forms a complex with WAVE2 (Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2) in MDA-MB-231 breast cancer cells and mouse brain extracts. Two separate regions of WAVE2 are involved in WAVE2-PKA complex formation. This complex localizes to the leading edge of MDA-MB-231 cells. PKA activation results in enlargement of the membrane protrusion. WAVE2 depletion impairs PKA localization at membrane protrusions and the enlargement of membrane protrusion induced by PKA activation. Together, these results suggest that WAVE2 works as an A-kinase-anchoring protein that recruits PKA at membrane protrusions and plays a role in the enlargement of membrane protrusions induced by PKA activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.