Trial reportJournal of the National Cancer Institute2010
Baseline characteristics of participants in the randomized national lung screening trial.
Trial report in Journal of the National Cancer Institute, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00047385 (National Lung Screening Trial A Randomized Trial Comparing Low-dose Helical CT With Chest Xray for Lung Cancer), which is not on this map. Cited by 155 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Lung Screening Trial A Randomized Trial Comparing Low-dose Helical CT With Chest Xray for Lung Cancer
Who cites it
155 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Screening for lung cancer: A systematic review of overdiagnosis and its implications.Molecular oncology · 2026Pooled it
- The prevalence of comorbidity in the lung cancer screening population: A systematic review and meta-analysis.Journal of medical screening · 2023Pooled it
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Racial and socioeconomic disparities in lung cancer screening in the United States: A systematic review.CA: a cancer journal for clinicians · 2021Pooled it
- Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2018Pooled it
- Psychological Burden Associated With Lung Cancer Screening: A Systematic Review.Clinical lung cancer · 2016Pooled it
- Patient-centered outcomes among lung cancer screening recipients with computed tomography: a systematic review.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Pooled it
- Guideline
- From randomized trials to the clinic: is it time to implement individual lung-cancer screening in clinical practice? A multidisciplinary statement from French experts on behalf of the French intergroup (IFCT) and the groupe d'Oncologie de langue francaise (GOLF).Annals of oncology : official journal of the European Society for Medical Oncology · 2013Guideline
- Pooled it
- Significant Incidental Findings in the National Lung Screening Trial and Diagnosis of Extrapulmonary Cancer.JAMA network open · 2026Trial
- A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials.Nature communications · 2025Trial
- Effect of Patient Navigation on Completion of Lung Cancer Screening in Vulnerable Populations.Journal of the National Comprehensive Cancer Network : JNCCN · 2024Trial
- Utilization of Diagnostic Procedures After Lung Cancer Screening in the National Lung Screening Trial.Journal of the American College of Radiology : JACR · 2023Trial
- Assessing Barriers and Facilitators to Lung Cancer Screening: Initial Findings from a Patient Navigation Intervention.Population health management · 2023Trial
- Effect of Incidental Findings Information on Lung Cancer Screening Intent: a Randomized Controlled Trial.Journal of general internal medicine · 2022Trial
- Aiding shared decision making in lung cancer screening: two decision tools.Journal of public health (Oxford, England) · 2021Trial
- Trial
- Lung Screen Uptake Trial (LSUT): Randomized Controlled Clinical Trial Testing Targeted Invitation Materials.American journal of respiratory and critical care medicine · 2020Trial
- Effect of a Patient Decision Aid on Lung Cancer Screening Decision-Making by Persons Who Smoke: A Randomized Clinical Trial.JAMA network open · 2020Trial
95 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
backgroundThe National Lung Screening Trial (NLST), a randomized study conducted at 33 US sites, is comparing lung cancer mortality among persons screened with reduced dose helical computerized tomography and among persons screened with chest radiograph. In this article, we present characteristics of the study population.
methodsEligible participants were aged 55-74 years and were current or former smokers with a cigarette smoking history of at least 30 pack-years. Randomization was stratified by site, sex, and age. To assess representativeness of the study population, demographic characteristics of individuals from the general population who met NLST age and smoking history inclusion criteria were obtained from the Tobacco Use Supplement of the US Census Bureau Current Population Surveys.
resultsThe NLST enrolled 53 456 persons, with 26 733 randomly assigned to chest radiograph screening and 26 723 to computerized tomography screening. Characteristics of the participants were as follows: 31 533 (59%) were men, 39 234 (73%) were younger than 65 years, 25 779 (48%) were current smokers, and 16 839 (32%) had a college or higher degree. Median cigarette exposure was 48 pack-years. Among Tobacco Use Supplement respondents who met NLST age and smoking history criteria, 59% were men, 65% were younger than 65 years, and 57% were current smokers. Median cigarette exposure among this group was 47 pack-years, and 14% had a college degree or higher.
conclusionThe NLST cohort has a distribution of sex and pack-year history that is similar to the component of the general US population that meets the major NLST eligibility criteria; however, NLST participants are younger, better educated, and less likely to be current smokers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.