ArticlePlant physiology2011
A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Oomycetes manipulate plant innate immunity through galacturonide oxidases.Nature communications · 2025Article
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- Treating Pythiosis with Antibacterial Drugs Targeting Protein Synthesis: An Overview.Journal of fungi (Basel, Switzerland) · 2024Review
- The Dynamic Interaction between Oil Palm andJournal of fungi (Basel, Switzerland) · 2024Article
- PcLRR-RK3, an LRR receptor kinase is required for growth andMycology · 2024Article
- Unveiling the Secretome of the Fungal Plant PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Promiscuous Domains in Eukaryotes and HAT Proteins in FUNGI Have Followed Different Evolutionary Paths.Journal of molecular evolution · 2022Article
- Mining oomycete proteomes for metalloproteases leads to identification of candidate virulence factors in Phytophthora infestans.Molecular plant pathology · 2021Article
- Uncovering the Role of Metabolism in Oomycete-Host Interactions Using Genome-Scale Metabolic Models.Frontiers in microbiology · 2021Review
- Gene Validation and Remodelling Using Proteogenomics ofFrontiers in microbiology · 2021Article
- Genome-Wide Analysis of Cyclophilin Proteins in 21 Oomycetes.Pathogens (Basel, Switzerland) · 2019Article
- Grammar of protein domain architectures.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- PHI-Nets: A Network Resource for Ascomycete Fungal Pathogens to Annotate and Identify Putative Virulence Interacting Proteins and siRNA Targets.Frontiers in microbiology · 2019Article
- Identification and functional analysis of the NLP-encoding genes from the phytopathogenic oomycete Phytophthora capsici.Molecular genetics and genomics : MGG · 2018Article
- GPCR-bigrams: Enigmatic signaling components in oomycetes.PLoS pathogens · 2018Article
- The Ancient Link between G-Protein-Coupled Receptors and C-Terminal Phospholipid Kinase Domains.mBio · 2018Article
- Comparative genomic analysis of the 'pseudofungus'Open biology · 2018Article
- Gene Expression and Silencing Studies in Phytophthora infestans Reveal Infection-Specific Nutrient Transporters and a Role for the Nitrate Reductase Pathway in Plant Pathogenesis.PLoS pathogens · 2016Article
- Article
- Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.PloS one · 2016Article
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4 authors.
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Abstract
Oomycetes comprise a diverse group of organisms that morphologically resemble fungi but belong to the stramenopile lineage within the supergroup of chromalveolates. Recent studies have shown that plant pathogenic oomycetes have expanded gene families that are possibly linked to their pathogenic lifestyle. We analyzed the protein domain organization of 67 eukaryotic species including four oomycete and five fungal plant pathogens. We detected 246 expanded domains in fungal and oomycete plant pathogens. The analysis of genes differentially expressed during infection revealed a significant enrichment of genes encoding expanded domains as well as signal peptides linking a substantial part of these genes to pathogenicity. Overrepresentation and clustering of domain abundance profiles revealed domains that might have important roles in host-pathogen interactions but, as yet, have not been linked to pathogenicity. The number of distinct domain combinations (bigrams) in oomycetes was significantly higher than in fungi. We identified 773 oomycete-specific bigrams, with the majority composed of domains common to eukaryotes. The analyses enabled us to link domain content to biological processes such as host-pathogen interaction, nutrient uptake, or suppression and elicitation of plant immune responses. Taken together, this study represents a comprehensive overview of the domain repertoire of fungal and oomycete plant pathogens and points to novel features like domain expansion and species-specific bigram types that could, at least partially, explain why oomycetes are such remarkable plant pathogens.
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