ArticleMolecular biology of the cell2011
Telomeric recombination induced by dysfunctional telomeres.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins.EMBO reports · 2025Article
- Article
- Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Journal of molecular biology · 2020Review
- ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.PLoS biology · 2020Article
- Telomere Maintenance-Associated PML Is a Potential Specific Therapeutic Target of Human Colorectal Cancer.Translational oncology · 2019Article
- Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT).International journal of molecular sciences · 2018Review
- Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.The Journal of experimental medicine · 2016Article
- TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.Scientific reports · 2016Article
- Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish.PLoS genetics · 2016Article
- On the road with WRAP53β: guardian of Cajal bodies and genome integrity.Frontiers in genetics · 2015Review
- Targeting DNA-PKcs and telomerase in brain tumour cells.Molecular cancer · 2014Article
- Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status.Cancer biology & therapy · 2014Article
- Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Nucleic acids research · 2014Article
- In situ visualization of telomere elongation patterns in human cells.Nucleic acids research · 2013Article
- Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation.PLoS genetics · 2013Article
- Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.The Journal of cell biology · 2012Article
- The potential utility of telomere-related markers for cancer diagnosis.Journal of cellular and molecular medicine · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after telomerase inhibition. We determined whether telomeric recombination can also be promoted by telomere dysfunction. We report for the first time that telomeric recombination can be induced in human telomerase-positive cancer cells with dysfunctional telomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.