ArticleThe American journal of tropical medicine and hygiene2010
Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Genetic polymorphisms of merozoite surface protein-1 ICB 5-6 in Vietnamese Plasmodium vivax isolates.Parasites, hosts and diseases · 2026Article
- Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador.Malaria journal · 2023Article
- Spatiotemporal Changes inMicroorganisms · 2022Article
- Higher Complexity of Infection and Genetic Diversity ofThe American journal of tropical medicine and hygiene · 2017Article
- Detection of Plasmodium using filter paper and nested PCR for patients with malaria in Sanliurfa, in Turkey.Malaria journal · 2016Article
- Diversity and evolutionary genetics of the three major Plasmodium vivax merozoite genes participating in reticulocyte invasion in southern Mexico.Parasites & vectors · 2015Article
- Molecular Evolution of PvMSP3α Block II in Plasmodium vivax from Diverse Geographic Origins.PloS one · 2015Article
- Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens.PLoS neglected tropical diseases · 2014Article
- Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination.Malaria journal · 2012Review
- Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea.PLoS neglected tropical diseases · 2011Article
- Genetic diversity of Plasmodium vivax malaria in China and Myanmar.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax.PloS one · 2011Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 200-kD merozoite surface protein of Plasmodium vivax (PvMSP-1) is one of the leading vaccine candidates against P. vivax malaria. However, the gene encoding PvMSP-1 (pvmsp1) is highly polymorphic and is a major obstacle to effective vaccine development. To further understand polymorphism in pvmsp1, we obtained 30 full-length pvmsp1 sequences from southeastern Turkey. Comparative analysis of sequences from Turkey and other areas showed substantially limited polymorphism. Substitutions were found at 280 and 162 amino acid sites in samples from other regions and those from Turkey, respectively. Eight substitutions were unique to Turkey. In one of them, D/E at position 1706 in the C-terminal 19-kD region, the K/E change at 1709 was the only polymorphism previously known. Limited diversity was also observed in microsatellites. Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.
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