Evidence map›Paper›PMID 21118817›Full record

ArticleThe Journal of biological chemistry2011

Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism.

Chi Ma, Santosh R D'Mello

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chi MaDepartment of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA.
Santosh R D'Mello
The University of Texas at Dallas · US

Funding

Signaling Pathways Regulating Neuronal SurvivalR01NS040408 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI D'MELLO, SANTOSH R · 2002 to 2018
$4.8M
Neuroprotective properties of c-Raf inhibitorsR01NS047201 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI D'MELLO, SANTOSH R · 2004 to 2008
$1.5M
NINDS NIH HHS NS040408NINDS NIH HHS NS047201NINDS NIH HHS R01 NS040408NINDS NIH HHS R01 NS047201
6 · The paper itself

Abstract

Histone deacetylase (HDAC) 7 is a member of the HDAC family of deacetylases. Although some of the HDAC proteins have been shown to regulate neuronal survival and death, whether HDAC7 has a similar role is not known. In this study, we show that HDAC7 protects neurons from apoptosis. In cerebellar granule neurons (CGNs) primed to undergo apoptosis by low potassium treatment, expression of HDAC7 protein is reduced. Reduced expression is also observed in CGNs induced to die by pharmacological inhibition of the proteasome, in cortical neurons treated with homocysteic acid, and in the striatum of R6/2 transgenic mice, a commonly used genetic model of Huntington disease. Forced expression of HDAC7 in cultured CGNs blocks low potassium-induced death, and shRNA-mediated suppression of its expression induces death in otherwise healthy neurons. HDAC7-mediated neuroprotection does not require its catalytic domain and cannot be inhibited by chemical inhibitors of HDACs. Moreover, pharmacological inhibitors of the PI3K-Akt or Raf-MEK-ERK signaling pathways or that of PKA, PKC, and Ca(2+)/calmodulin-dependent protein kinase fail to reduce neuroprotection by HDAC7. We show that stimulation of c-jun expression, an essential feature of neuronal death, is prevented by HDAC7. shRNA-mediated suppression of HDAC7 expression leads to an increase in c-jun expression. Inhibition of c-jun expression by HDAC7 is mediated at the transcriptional level by its direct association with the c-jun gene promoter. Taken together, our results indicate that HDAC7 is a neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of c-jun expression.

Indexed as

AnimalsApoptosisCell Line, TumorCerebellumExtracellular Signal-Regulated MAP KinasesFemaleGene Expression RegulationHistone Deacetylase InhibitorsHistone DeacetylasesMaleMAP Kinase Kinase KinasesMAP Kinase Signaling SystemMiceMice, TransgenicNeuronsPhosphatidylinositol 3-KinasesExtracellular Signal-Regulated MAP KinasesHdac7 protein, mouseHistone Deacetylase InhibitorsHistone DeacetylasesMAP Kinase Kinase KinasesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-jun

Identifiers

PMID21118817
PMCPMC3039335
OpenAlexW2028597345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.