ArticleRetrovirology2010
Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques.
Article in Retrovirology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Large expansion of plasma commensal viruses is associated with SIV pathogenesis inScience advances · 2024Article
- Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment.Retrovirology · 2018Article
- Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.Scientific reports · 2017Article
- Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239.Immunology · 2016Article
- Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques.Chinese medicine · 2016Article
- Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.Journal of immunology research · 2015Article
- Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress.Dong wu xue yan jiu = Zoological research · 2014Review
- SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans.Retrovirology · 2013Review
- Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.Immunogenetics · 2013Article
- Efficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques.Cellular & molecular immunology · 2012Article
- A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques.Journal of medical primatology · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have demonstrated that SIV infection progresses more slowly to experimental AIDS in Chinese rhesus macaques (Ch Rhs) than in Indian rhesus macaques (Ind Rhs). Here we investigated the dynamic and functional changes in dendritic cell (DC) subsets in SIVmac239-infected Ch Rhs.
resultsThe numbers of both mDC and pDC strongly fluctuated but were not significantly changed during the acute and chronic phases of infection. However, the concentration of both poly (I:C)-induced IL-12 and HSV-1-induced IFN-α significantly increased in the acute phase of infection but returned to normal levels at the chronic phase of infection. The peak of IFN-α emerged earlier than that of IL-12, and it had a significantly positive correlation with IL-12, which indicated that IFN-α may initiate the immune activation. We also found that only the concentration of IFN-α was positively correlated with CD4+ T-cell counts, but it was negatively correlated with viral load.
conclusionHigh levels of IFN-α in the early stage of infection may contribute to effective control of virus replication, and normal levels of IFN-α during chronic infection may help Ch Rhs resist the disease progression. The change in DC subsets dynamics and cytokine production may help further our understanding of why Ch Rhs are able to live longer without progressing to an AIDS-like illness.
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