ArticleBMC genomics2010
In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Aspartimide Modification in RiPP Natural Products.Biochemistry · 2026Review
- Embleporicin: A Novel Class I Lanthipeptide from the ActinobacteriaAntibiotics (Basel, Switzerland) · 2024Article
- Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain.Royal Society open science · 2024Article
- Large-scale Bioinformatic Study of Graspimiditides and Structural Characterization of Albusimiditide.ACS chemical biology · 2023Article
- A novel biocontrol agent Bacillus velezensis K01 for management of gray mold caused by Botrytis cinerea.AMB Express · 2023Article
- After a century of nisin research - where are we now?FEMS microbiology reviews · 2023Review
- Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides.FEMS microbiology reviews · 2023Review
- Improved production of class I lanthipeptides inChemical science · 2023Article
- Bioinformatic mining for RiPP biosynthetic gene clusters in Bacteroidales reveals possible new subfamily architectures and novel natural products.Frontiers in microbiology · 2023Article
- Divergent Evolution of Lanthipeptide Stereochemistry.ACS chemical biology · 2022Article
- The Unexplored Wealth of Microbial Secondary Metabolites: the Sphingobacteriaceae Case Study.Microbial ecology · 2022Article
- Structural Analysis of Class I Lanthipeptides fromACS chemical biology · 2021Article
- A plant endophyte Staphylococcus hominis strain MBL_AB63 produces a novel lantibiotic, homicorcin and a position one variant.Scientific reports · 2021Article
- New developments in RiPP discovery, enzymology and engineering.Natural product reports · 2021Review
- Genomic analysis suggests Salinispora is a rich source of novel lanthipeptides.Molecular genetics and genomics : MGG · 2020Article
- Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family.BMC genomics · 2020Article
- Article
- Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota.Frontiers in microbiology · 2020Article
- Article
- Comparative Transcriptome Analysis ofAntibiotics (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are those in which lanthionine residues are introduced into the structural peptide (LanA) through the activity of separate lanthionine dehydratase (LanB) and lanthionine synthetase (LanC) enzymes. Here we take advantage of the conserved nature of LanC enzymes to devise an in silico approach to identify potential lantibiotic-encoding gene clusters in genome sequenced bacteria.
resultsIn total 49 novel type 1 lantibiotic clusters were identified which unexpectedly were associated with species, genera and even phyla of bacteria which have not previously been associated with lantibiotic production.
conclusionsMultiple type 1 lantibiotic gene clusters were identified at a frequency that suggests that these antimicrobials are much more widespread than previously thought. These clusters represent a rich repository which can yield a large number of valuable novel antimicrobials and biosynthetic enzymes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.