ArticleBMC neuroscience2010
Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain.Molecular psychiatry · 2024Article
- Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling.Molecular psychiatry · 2022Article
- Behavioral defects and downregulation of hippocampal BDNF and nNOS expression in db/db mice did not improved by chronic TGF-β2 treatment.Frontiers in physiology · 2022Article
- Differential effects of ethanol on behavior and GABAScientific reports · 2020Article
- Environmental concentration of fluoxetine disturbs larvae behavior and increases the defense response at molecular level in zebrafish (Danio rerio).Environmental science and pollution research international · 2019Article
- Alpha-Synuclein RNA Expression is Increased in Major Depression.International journal of molecular sciences · 2019Article
- DNA Microarray-Based Screening and Characterization of Traditional Chinese Medicine.Microarrays (Basel, Switzerland) · 2017Review
- Systems Genomics Support for Immune and Inflammation Hypothesis of Depression.Current neuropharmacology · 2016Review
- Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.Translational psychiatry · 2015Article
- Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression.Translational psychiatry · 2015Article
- Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints.Neural regeneration research · 2014Article
- Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs.BMC genomics · 2013Article
- Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons.Chemistry & biology · 2013Article
- Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment.BMC genomics · 2013Article
- Analysis of region-specific changes in gene expression upon treatment with citalopram and desipramine reveals temporal dynamics in response to antidepressant drugs at the transcriptome level.Psychopharmacology · 2012Article
- Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.Psychopharmacology · 2012Article
- Synuclein modulation of monoamine transporters.FEBS letters · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe molecular and biological mechanisms by which many antidepressants function are based on the monoamine depletion hypothesis. However, the entire cascade of mechanisms responsible for the therapeutic effect of antidepressants has not yet been elucidated.
resultsWe used a genome-wide microarray system containing 30,000 clones to evaluate total RNA that had been isolated from the brains of treated rats to identify the genes involved in the therapeutic mechanisms of various antidepressants, a tricyclic antidepressant (imipramine). a selective serotonin reuptake inhibitor (fluoxetine), a monoamine oxidase inhibitor (phenelzine) and psychoactive herbal extracts of Nelumbinis Semen (NS). To confirm the differential expression of the identified genes, we analyzed the amount of mRNA that was isolated from the hippocampus of rats that had been treated with antidepressants by real-time RT-PCR using primers specific for selected genes of interest. These data demonstrate that antidepressants interfere with the expression of a large array of genes involved in signaling, survival and protein metabolism, suggesting that the therapeutic effect of these antidepressants is very complex. Surprisingly, unlike other antidepressants, we found that the standardized herbal medicine, Nelumbinis Semen, is free of factors that can induce neurodegenerative diseases such as caspase 8, α-synuclein, and amyloid precursor protein. In addition, the production of the inflammatory cytokine, IFNγ, was significantly decreased in rat hippocampus in response to treatment with antidepressants, while the inhibitory cytokine, TGFβ, was significantly enhanced.
conclusionsThese results suggest that antidepressants function by regulating neurotransmission as well as suppressing immunoreactivity in the central nervous system.
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