ArticleBMC medical imaging2010
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis.
Article in BMC medical imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Videodensitometric analysis of advanced carotid plaque: correlation with MMP-9 and TIMP-1 expression.Cardiovascular ultrasound · 2011Trial
- The changing epidemiology of human type 2 diabetes-associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities.Journal of internal medicine · 2026Review
- High-Resolution MRI-Based Clinical-Radiological Phenotypes of Carotid Vulnerability and Long-Term Outcomes After Carotid Revascularization: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors.Translational stroke research · 2026Observational
- Associations between carotid plaque shape, biomechanical parameters, and ischemic stroke in mild carotid stenosis with a single plaque.Ultrasonography (Seoul, Korea) · 2024Article
- Predictive Value of Non-high-Density Lipoprotein Cholesterol and Neutrophil-Lymphocyte Ratio for Coronary Artery Vulnerable Plaques in Type 2 Diabetes Mellitus.Frontiers in cardiovascular medicine · 2022Article
- Complex Aortic Arch Atherosclerosis in Acute Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation.Journal of atherosclerosis and thrombosis · 2021Article
- Association between type 2 diabetes mellitus, especially recently uncontrolled glycemia, and intracranial plaque characteristics: A high-resolution magnetic resonance imaging study.Journal of diabetes investigation · 2020Article
- Carotid plaque imaging profiling in subjects with risk factors (diabetes and hypertension).Cardiovascular diagnosis and therapy · 2020Review
- Negative Carotid Artery Remodeling in Early Type 2 Diabetes Mellitus and Increased Carotid Plaque Vulnerability in Obesity as Assessed by Magnetic Resonance Imaging.Journal of the American Heart Association · 2018Article
- Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2017Article
- Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
- Molecular Cardiovascular Magnetic Resonance: Current Status and Future Prospects.Current cardiology reports · 2016Review
- Molecular magnetic resonance imaging of atherosclerotic vessel wall disease.European radiology · 2016Review
- Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque.Radiology research and practice · 2015Review
- Molecular imaging of inflammation in atherosclerosis.Theranostics · 2013Review
- Are two readers more reliable than one? A study of upper neck ligament scoring on magnetic resonance images.BMC medical imaging · 2013Article
- MRI plaque imaging detects carotid plaques with a high risk for future cerebrovascular events in asymptomatic patients.PloS one · 2013Article
- An initial evaluation of analyser-based phase-contrast X-ray imaging of carotid plaque microstructure.The British journal of radiology · 2013Article
- Cardiovascular disease in children and adolescents with diabetes: where are we, and where are we going?Diabetes technology & therapeutics · 2012Review
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlaque imaging based on magnetic resonance imaging (MRI) represents a new modality for risk assessment in atherosclerosis. It allows classification of carotid plaques in high-risk and low-risk lesion types (I-VIII). Type 2 diabetes mellitus (DM 2) represents a known risk factor for atherosclerosis, but its specific influence on plaque vulnerability is not fully understood. This study investigates whether MRI-plaque imaging can reveal differences in carotid plaque features of diabetic patients compared to nondiabetics.
methods191 patients with moderate to high-grade carotid artery stenosis were enrolled after written informed consent was obtained. Each patient underwent MRI-plaque imaging using a 1.5-T scanner with phased-array carotid coils. The carotid plaques were classified as lesion types I-VIII according to the MRI-modified AHA criteria. For 36 patients histology data was available.
resultsEleven patients were excluded because of insufficient MR-image quality. DM 2 was diagnosed in 51 patients (28.3%). Concordance between histology and MRI-classification was 91.7% (33/36) and showed a Cohen's kappa value of 0.81 with a 95% CI of 0.98-1.15. MRI-defined high-risk lesion types were overrepresented in diabetic patients (n = 29; 56.8%). Multiple logistic regression analysis revealed association between DM 2 and MRI-defined high-risk lesion types (OR 2.59; 95% CI [1.15-5.81]), independent of the degree of stenosis.
conclusionDM 2 seems to represent a predictor for the development of vulnerable carotid plaques irrespective of the degree of stenosis and other risk factors. MRI-plaque imaging represents a new tool for risk stratification of diabetic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.