ArticleGenome biology2010
Comparative genomics reveals birth and death of fragile regions in mammalian evolution.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Fixed Allele Differences Associated With the Centromere Reveal Chromosome Morphology and Rearrangements in a Reptile (Varanus acanthurus BOULENGER).Molecular biology and evolution · 2023Article
- First Comprehensive Characterization of Phayre's Leaf-Monkey (Frontiers in genetics · 2022Article
- Large-scale mammalian genome rearrangements coincide with chromatin interactions.Bioinformatics (Oxford, England) · 2019Article
- Article
- Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family.BMC genomics · 2016Article
- Breaking Good: Accounting for Fragility of Genomic Regions in Rearrangement Distance Estimation.Genome biology and evolution · 2016Article
- Sampling and counting genome rearrangement scenarios.BMC bioinformatics · 2015Article
- A high resolution map of mammalian X chromosome fragile regions assessed by large-scale comparative genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- What is the difference between the breakpoint graph and the de Bruijn graph?BMC genomics · 2014Article
- First detailed reconstruction of the karyotype of Trachypithecus cristatus (Mammalia: Cercopithecidae).Molecular cytogenetics · 2013Article
- 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.PloS one · 2012Article
- Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
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2 authors.
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Abstract
backgroundAn important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals raised some doubts about their existence.
resultsHere we demonstrate that fragile regions are subject to a birth and death process, implying that fragility has a limited evolutionary lifespan.
conclusionsThis finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions as a phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome.
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