ArticleAnnals of human genetics2011
Importance measures for epistatic interactions in case-parent trios.
Article in Annals of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A method for finding epistatic effects of maternal and fetal variants.Frontiers in genetics · 2025Article
- GADGETS: a genetic algorithm for detecting epistasis using nuclear families.Bioinformatics (Oxford, England) · 2022Article
- Case-Parent Trio Studies in Cleft Lip and Palate.Global medical genetics · 2020Review
- Bio-collections in autism research.Molecular autism · 2017Review
- A forest-based feature screening approach for large-scale genome data with complex structures.BMC genetics · 2015Article
- Detecting disease variants in case-parent trio studies using the bioconductor software package trio.Genetic epidemiology · 2014Article
- An approach to predict the risk of glaucoma development by integrating different attribute data.SpringerPlus · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Ensemble methods (such as Bagging and Random Forests) take advantage of unstable base learners (such as decision trees) to improve predictions, and offer measures of variable importance useful for variable selection. LogicFS has been proposed as such an ensemble learner for case-control studies when interactions of single nucleotide polymorphisms (SNPs) are of particular interest. LogicFS uses bootstrap samples of the data and employs the Boolean trees derived in logic regression as base learners to create ensembles of models that allow for the quantification of the contributions of epistatic interactions to the disease risk. In this article, we propose an extension of logicFS suitable for case-parent trio data, and derive an additional importance measure that is much less influenced by linkage disequilibrium between SNPs than the measure originally used in logicFS. We illustrate the performance of the novel procedure in simulation studies and in a case study of 461 case-parent trios with autistic children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.