ArticleThe Biochemical journal2011
Target genes of the largest human SWI/SNF complex subunit control cell growth.
Article in The Biochemical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- A novel SWI/SNF complex promotes triple-negative breast cancer progression.Cellular & molecular biology letters · 2025Article
- ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease.Experimental & molecular medicine · 2022Article
- CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells.Oncology research · 2019Article
- A potentially functional variant of ARID1B interacts with physical activity in association with risk of hepatocellular carcinoma.Oncotarget · 2017Article
- The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.Genetics · 2016Article
- Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression.Cell cycle (Georgetown, Tex.) · 2016Review
- Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling.American journal of human genetics · 2015Article
- ARID1A Is Essential for Endometrial Function during Early Pregnancy.PLoS genetics · 2015Article
- Inactivation of chromatin remodeling factors sensitizes cells to selective cytotoxic stress.Biologics : targets & therapy · 2014Article
- ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines.British journal of cancer · 2013Article
- ARID1A mutations in cancer: another epigenetic tumor suppressor?Cancer discovery · 2013Review
- ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.Molecular and cellular biology · 2013Article
- SWI/SNF chromatin remodeling complex: a new cofactor in reprogramming.Stem cell reviews and reports · 2012Review
- Article
- ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.Cancer research · 2011Article
- Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer.Nature genetics · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The largest subunit of the mammalian SWI/SNF-A or BAF (BRG1-associated factor) chromatin-remodelling complex is encoded by two related cDNAs hOsa1/BAF250a and hOsa2/BAF250b that are unique to the BAF complex and absent in the related PBAF (Polybromo BAF). hOsa/BAF250 has been shown to interact with transcriptional activators and bind to DNA suggesting that it acts to target the remodelling complex to chromatin. To better understand the functions of hOsa2, we established inducible stable HeLa cell lines over-expressing FLAG-hOsa2 or a derivative lacking the ARID (AT-rich interactive domain) DNA-binding domain. Immunopurification of complexes containing hOsa2 that was followed by mass spectrometry and immunoblotting demonstrated the presence of BRG1 and known BAFs, but not hOsa1 or hBRM. Deletion of the ARID did not compromise the integrity of the complex. Induction of hOsa2 expression caused impaired cell growth and accumulation of cells in the G0/G1 cell cycle phase. Elevated levels of the p53 and p21 proteins were detected in these cells while c-Myc mRNA and protein levels were found to decrease. Chromatin immunoprecipitation and reporter assays suggested that hOsa2 had a direct effect on c-myc and p21 promoter activity. Thus hOsa2 plays an important role in controlling genes regulating the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.