Evidence map›Paper›PMID 21118031›Full record

ReviewExpert opinion on drug delivery2010

Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs.

Baris E Polat, Daniel Blankschtein, Robert Langer

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug delivery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Low-Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery.Advances in pharmacological and pharmaceutical sciences · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Engineering of tetanus toxoid-loaded polymeric microneedle patches.Drug delivery and translational research · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. The Effects of Green Tea (Healthcare (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Metals in Imaging of Alzheimer's Disease.International journal of molecular sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Baris E PolatMassachusetts Institute of Technology, Department of Chemical Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Daniel Blankschtein
Robert Langer
Massachusetts Institute of Technology · US

Funding

Ultrasound Polymeric Drug DeliveryR01EB000351 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2002 to 2013
$3.0M
NIBIB NIH HHS EB-00351NIBIB NIH HHS R01 EB000351
6 · The paper itself

Abstract

importance of the fieldTransdermal delivery of macromolecules provides an attractive alternative route of drug administration when compared to oral delivery and hypodermic injection because of its ability to bypass the harsh gastrointestinal tract and deliver therapeutics non-invasively. However, the barrier properties of the skin only allow small, hydrophobic permeants to traverse the skin passively, greatly limiting the number of molecules that can be delivered via this route. The use of low-frequency ultrasound for the transdermal delivery of drugs, referred to as low-frequency sonophoresis (LFS), has been shown to increase skin permeability to a wide range of therapeutic compounds, including both hydrophilic molecules and macromolecules. Recent research has demonstrated the feasibility of delivering proteins, hormones, vaccines, liposomes and other nanoparticles through LFS-treated skin. In vivo studies have also established that LFS can act as a physical immunization adjuvant. LFS technology is already clinically available for use with topical anesthetics, with other technologies currently under investigation. AREAS COVERED IN THIS REVIEW: This review provides an overview of mechanisms associated with LFS-mediated transdermal delivery, followed by an in-depth discussion of the current applications of LFS technology for the delivery of hydrophilic drugs and macromolecules, including its use in clinical applications. WHAT THE READER WILL GAIN: The reader will gain an insight into the field of LFS-mediated transdermal drug delivery, including how the use of this technology can improve on more traditional drug delivery methods. TAKE HOME MESSAGE: Ultrasound technology has the potential to impact many more transdermal delivery platforms in the future due to its unique ability to enhance skin permeability in a controlled manner.

Indexed as

Administration, CutaneousBiological TransportDrug Delivery SystemsHumansHydrophobic and Hydrophilic InteractionsMacromolecular SubstancesPermeabilityPharmaceutical PreparationsPhonophoresisSkin AbsorptionMacromolecular SubstancesPharmaceutical Preparations

Identifiers

PMID21118031
PMCPMC3050019
OpenAlexW1586224712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.