ArticleAnalytical chemistry2011
Ultrahigh-resolution differential ion mobility spectrometry using extended separation times.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Design of a New FAIMS Device With Replaceable Accessories and Analysis of the Impact of Spacing.Rapid communications in mass spectrometry : RCM · 2026Article
- New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Transmitting and Filtering Ions in the Open Air by Applying Spirally Rotating Electric Fields to a Flexible and Segmented Stacked Ring Ion Guide.Analytical chemistry · 2025Article
- Oxygen enhanced plasma discharge and its application as carrier gas for high-field asymmetric ion mobility spectroscopy.Analytical and bioanalytical chemistry · 2025Article
- Coated Blade Spray Ion Mobility Spectrometry.Analytical chemistry · 2024Article
- Electrospray Ion Mobility Spectrometer Based on Flexible Printed-Circuit Board Electrodes with Improved Resolving Power.Analytical chemistry · 2023Article
- Dynamic Time-Warping Correction for Shifts in Ultrahigh Resolving Power Ion Mobility Spectrometry and Structures for Lossless Ion Manipulations.Journal of the American Society for Mass Spectrometry · 2021Article
- Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations.Analytical chemistry · 2017Article
- Increased Ion Transmission for Differential Ion Mobility Combined with Mass Spectrometry by Implementation of a Flared Inlet Capillary.Journal of the American Society for Mass Spectrometry · 2017Article
- Improved Differential Ion Mobility Separations Using Linked Scans of Carrier Gas Composition and Compensation Field.Journal of the American Society for Mass Spectrometry · 2015Article
- Optimization of peptide separations by differential ion mobility spectrometry.Journal of the American Society for Mass Spectrometry · 2014Article
- Improved isobaric tandem mass tag quantification by ion mobility mass spectrometry.Rapid communications in mass spectrometry : RCM · 2014Article
- Differential ion mobility separations in up to 100% helium using microchips.Journal of the American Society for Mass Spectrometry · 2014Article
- High-definition differential ion mobility spectrometry with resolving power up to 500.Journal of the American Society for Mass Spectrometry · 2013Article
- Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.Mass spectrometry (Tokyo, Japan) · 2013Article
- High-field asymmetric waveform ion mobility spectrometry for mass spectrometry-based proteomics.Expert review of proteomics · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ion mobility spectrometry (IMS), and particularly differential IMS or field asymmetric waveform IMS (FAIMS), is emerging as a versatile tool for separation and identification of gas-phase ions, especially in conjunction with mass spectrometry. For over two decades since its inception, the utility of FAIMS was constrained by resolving power (R) of less than ∼20. Stronger electric fields and optimized gas mixtures have recently raised achievable R to ∼200, but further progress with such approaches is impeded by electrical breakdown. However, the resolving power of planar FAIMS devices using any gas and field intensity scales as the square root of separation time (t). Here, we extended t from the previous maximum of 0.2 s up to 4-fold by reducing the carrier gas flow and increased the resolving power by up to 2-fold as predicted, to >300 for multiply charged peptides. The resulting resolution gain has enabled separation of previously "co-eluting" peptide isomers, including folding conformers and localization variants of modified peptides. More broadly, a peak capacity of ∼200 has been reached in tryptic digest separations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.