ArticleMolecular microbiology2010
Form equals function? Bacterial shape and its consequences for pathogenesis.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Morphologic design of nanostructures for enhanced antimicrobial activity.Journal of nanobiotechnology · 2022Review
- Trick or Treating in Forensics-The Challenge of the Saliva Microbiome: A Narrative Review.Microorganisms · 2020Review
- Accumulation of Peptidoglycan O-Acetylation Leads to Altered Cell Wall Biochemistry and Negatively Impacts Pathogenesis Factors of Campylobacter jejuni.The Journal of biological chemistry · 2016Article
- Cell-Size Homeostasis and the Incremental Rule in a Bacterial Pathogen.Biophysical journal · 2015Article
- Morphological and Bactericidal Effects of Different Antibiotics on Helicobacter pylori.Jundishapur journal of microbiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Bacteria exhibit a wide variety of morphologies. This could simply be a consequence of an elaboration of bacterial cellular architecture akin to the famous decorative but not structurally essential Spandrels in the Basilica di San Marco in Venice that are a side-effect of an adaptation, rather than a direct product of natural selection. However, it is more likely that particular morphologies facilitate a specific function in cellular physiology. Two recent publications including one in this issue of Molecular Microbiology and another in Cell provide new insights into the molecular basis for the helical shape of the bacterium Helicobacter pylori and the role of this shape in pathogenesis. They identify a novel endopeptidase that is necessary to generate the helical shape by processing the peptidoglycan and report that catalytically inactive mutants lead to defects in colonization that appear to be independent of an effect on cellular motility. Here, we put these findings in the context of some of what is known about peptidoglycan and cell shape and suggest that the role of this endopeptidase in forming coccoid morphology may be critical for pathogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.