ArticleMolecular biology reports2011
Molecular characterization and NF-κB-regulated transcription of selenoprotein S from the Bama mini-pig.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Current views on selenoprotein S in the pathophysiological processes of diabetes-induced atherosclerosis: potential therapeutics and underlying biomarkers.Diabetology & metabolic syndrome · 2024Review
- Research progress on anti-stress nutrition strategies in swine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Selenoprotein S: A versatile disordered protein.Archives of biochemistry and biophysics · 2022Review
- Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.Scientific reports · 2022Article
- Comparative Transcriptome Analysis Provides Insight into Spatio-Temporal Expression Characteristics and Genetic Regulatory Network in Postnatal Developing Subcutaneous and Visceral Fat of Bama Pig.Frontiers in genetics · 2022Article
- Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population.Bioscience reports · 2018Article
- Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?Cardiovascular diabetology · 2017Review
- The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study.Cardiovascular diabetology · 2016Article
- Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene.Molecular biology reports · 2014Article
- Article
- Transcriptome profiling identifies differentially expressed genes in postnatal developing pituitary gland of miniature pig.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Molecular cloning, tissue distribution and ontogenetic expression of Xiang pig chemerin and its involvement in regulating energy metabolism through Akt and ERK1/2 signaling pathways.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenoprotein S (SelS), a member of selenoprotein family, plays important regulatory function in inflammation and metabolic diseases. SelS expression is up-regulated response to the inflammatory stimulus in many mammal cells, animal models as well as patients. In order to further understand the function of SelS gene, molecular characterization and transcriptional regulation of SelS from a Bama mini-pig were analyzed in the present study. The results showed that pig SelS encoded a protein of 190 amino acid with estimated molecular weight of 21.23 kDa and pI of 9.526. The genomic structure, promoter and deduced amino acid sequence were analyzed and found to share high similarity with those of human SelS. Pig SelS fusion protein was demonstrated to localize in the cytoplasm by fluorescence microscopy. Real-time PCR revealed the ubiquitous expression pattern of pig SelS in diverse tissues, a high level expression was observed in the liver and lung, relatively low expression in other tissues, especially in muscle. Promoter deletion analysis further suggests that an NF-κB binding site within the SelS promoter is responsible for the up-regulation of SelS transcription.
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