ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011
Inadequate symptom control in advanced cancer patients across Europe.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Telephone interventions for symptom management in adults with cancer.The Cochrane database of systematic reviews · 2020Pooled it
- MASCC recommendations on the management of constipation in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Guideline
- Opioid Rotation in Cancer Pain Treatment.Deutsches Arzteblatt international · 2018Pooled it
- Systematic review of sleep disorders in cancer patients: can the prevalence of sleep disorders be ascertained?Cancer medicine · 2015Pooled it
- Feasibility and acceptance of electronic monitoring of symptoms and syndromes using a handheld computer in patients with advanced cancer in daily oncology practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Trial
- Article
- Occupational therapists' role in sleep management in palliative care: A cross-sectional survey.The British journal of occupational therapy · 2025Article
- Validation of the Turkish adaptation of FACETS-OF-PPC: a multidimensional outcome measure for pediatric palliative care.Frontiers in oncology · 2025Article
- Inadequate management of opioid-induced constipation in European cancer pain patients: results of a real-world, multicentre, observational study ("E-StOIC").Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Symptom Prevalence and Place of Death Preference in Advanced Cancer Patients: Factors Associated With the Achievement of Home Death.The American journal of hospice & palliative care · 2022Article
- A pilot randomized placebo-controlled study on modified MaZiRenWan: a formulated Chinese medicine to relieve constipation for palliative cancer patients.Chinese medicine · 2022Article
- Article
- Severity of constipation related to palonosetron during first-line chemotherapy: a retrospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Observational
- A national cross-sectional survey of constipation in patients attending cancer centres in Ireland.HRB open research · 2021Article
- 'Take more laxatives was their answer to everything': A qualitative exploration of the patient, carer and healthcare professional experience of constipation in specialist palliative care.Palliative medicine · 2020Article
- Evidence, safety and recommendations for when to use acupuncture for treating cancer related symptoms: a narrative review.Integrative medicine research · 2019Review
- Nursing's Potential to Address the Growing Cancer Burden in Low- and Middle-Income Countries.Journal of global oncology · 2016Article
- Effect on Symptom Management Education Receiving Patients of Chemotherapy.Journal of cancer education : the official journal of the American Association for Cancer Education · 2016Article
- Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids.Clinical and translational gastroenterology · 2015Article
- Toward a systematic approach to opioid rotation.Journal of pain research · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to examine the adequacy of treatment for constipation, nausea, depression and poor sleep and the factors associated with inadequate symptom control in cancer patients receiving opioids.
methodsPatients receiving strong opioids for cancer pain were recruited from 17 centres in 11 European countries. By using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire C30, 1,938 patients reported their symptoms at four-point scales. Health care providers assessed symptoms at corresponding four-point scales and registered use of medications, demographic and disease-related variables. Symptomatic treatment was scored as 1 if not administered during the past 24 h and as 2 if administered. Adequacy of treatment was evaluated by subtracting the patients' symptom score from the treatment score. Negative scores, caused by either no treatment or ineffective treatment of a symptom, were interpreted as inadequate treatment.
resultsApproximately 60% of patients with constipation, depression or poor sleep and 45% of nauseated patients were inadequately treated. Numbers of inadequately treated patients varied between countries. In general, underestimation of symptom intensity by health care providers (p < 0.001), low performance status (p < 0.05) and recent initiation of opioids (p < 0.05) increased the risk of inadequate treatment. The subset of demographic- and disease-related factors associated with inadequate treatment varied between the symptoms investigated.
conclusionsInadequate treatment, either no treatment or ineffective treatment, was frequent in cancer patients. There were subgroups of patients at particular risk for inadequate treatment, which might need additional attention from health care providers for achievement of adequate symptom control.
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