ArticleCellular and molecular bioengineering2010
Effects of Axial Stretch on Cell Proliferation and Intimal Thickness in Arteries in Organ Culture.
Article in Cellular and molecular bioengineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Investigation of osteogenesis and angiogenesis in perfusion bioreactors using improved multi-layer PCL-nHA-nZnO electrospun scaffolds.Biotechnology letters · 2023Article
- Numerical simulations of the nonsymmetric growth and remodeling of arteries under axial twisting.Journal of biomechanics · 2022Article
- Focus on time: dynamic imaging reveals stretch-dependent cell relaxation and nuclear deformation.Biophysical journal · 2021Article
- Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study.The Journal of pathology · 2020Article
- Arterial wall remodeling under sustained axial twisting in rats.Journal of biomechanics · 2017Article
- A Strain Feedback Compensation Method during Cell Tensile Experiments.Journal of healthcare engineering · 2017Article
- Buckling Reduces eNOS Production and Stimulates Extracellular Matrix Remodeling in Arteries in Organ Culture.Annals of biomedical engineering · 2016Article
- Subfailure Overstretch Injury Leads to Reversible Functional Impairment and Purinergic P2X7 Receptor Activation in Intact Vascular Tissue.Frontiers in bioengineering and biotechnology · 2016Article
- Mechanical stretch: physiological and pathological implications for human vascular endothelial cells.Vascular cell · 2015Review
- Smooth muscle cell contraction increases the critical buckling pressure of arteries.Journal of biomechanics · 2013Article
- Alterations in Pulse Pressure Affect Artery Function.Cellular and molecular bioengineering · 2012Article
- Mechanical stretching for tissue engineering: two-dimensional and three-dimensional constructs.Tissue engineering. Part B, Reviews · 2012Review
- Mechanical buckling of artery under pulsatile pressure.Journal of biomechanics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Intimal hyperplasia (IH) remains the major cause of intermediate and long-term failure of vascular grafts and endovascular interventions. Arteries are subjected to a significant longitudinal stress in addition to the shear stress and tensile stress from the blood flow. The aim of this study was to determine the effect of axial stretch on cell proliferation and IH in arteries. Porcine carotid arteries, intact or endothelial cell (EC) denudated, were maintained ex vivo at different stretch ratios (1.3, 1.5, and 1.8) and flow rates (16 or 160 mL/min) while remaining at physiologic pressure for 7 days. The viability of the arteries was verified with norepinephrine, carbachol, and sodium nitroprusside stimulations, and the cell proliferation was detected using bromodeoxyuridine labeling and immunostaining. Our results showed that the axial stretch ratio did not significantly affect intimal thickness and cell proliferation in normal arteries. However, axial stretch increased the neointimal thickness in EC denudated arteries cultured under low flow conditions. The cell proliferation increased significantly in the intima and inner half of the media of the EC denudated arteries under normal or elevated axial stretch in comparison to intact arteries at the same stretch ratio. These results demonstrated that axial stretch with EC denudation and low flow increases neointimal formation and cell proliferation in the arteries.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.