ArticleACS medicinal chemistry letters2010
Concise syntheses of the abyssinones and discovery of new inhibitors of prostate cancer and MMP-2 expression.
Article in ACS medicinal chemistry letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 42 citations in OpenAlex.
- Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity.Molecular diversity · 2024Article
- Review
- Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis.Chemical science · 2019Article
- Article
- A biomimetic strategy to access the silybins: total synthesis of (-)-isosilybin A.Organic letters · 2015Article
- Catalytic enantioselective synthesis of 2-aryl-chromenes.Chemical science · 2014Article
- A Concise Enantioselective Synthesis and Cytotoxic Evaluation of the Anticancer Rotenoid Deguelin Enabled by a Tandem Knoevenagel/Conjugate Addition/Decarboxylation Sequence.Chemical science · 2013Article
- Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades.Acta pharmacologica Sinica · 2012Review
- Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.ChemMedChem · 2012Article
- Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones.European journal of organic chemistry · 2012Article
- Enantioselective synthesis of (-)-exiguolide by iterative stereoselective dioxinone-directed Prins cyclizations.Angewandte Chemie (International ed. in English) · 2011Article
- Highly stereoselective Brønsted acid catalyzed synthesis of spirooxindole pyrans.Organic letters · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hydrogen-bonding catalysis is an emerging field that facilitates rapid access to medicinally relevant enantioenriched small molecules. Here, we report the first asymmetric total syntheses of four members of the abyssinone class of natural products (I, II, III, and IV 4´-OMe) via quinine- or quinidine-derived thiourea-catalyzed intramolecular conjugate additions of β-keto ester alkylidenes. This concise strategy includes a tandem deprotection/decarboxylation final step that delivers all four natural products and their corresponding antipodes. A preliminary evaluation of all of these small molecules against a metastatic human prostate cancer cell line has identified that these compounds selectively and differentially inhibit cell growth and downregulate the expression of matrix metalloproteinase-2 (MMP-2) at non-toxic concentrations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.