Trial reportJournal of acquired immune deficiency syndromes (1999)2011
Psychiatric risk factors for HIV disease progression: the role of inconsistent patterns of antiretroviral therapy utilization.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Critical Review: When the Party is Over: A Systematic Review of Behavioral Interventions for Substance-Using Men Who Have Sex with Men.Journal of acquired immune deficiency syndromes (1999) · 2016Pooled it
- Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis.Journal of acquired immune deficiency syndromes (1999) · 2011Pooled it
- A Web-Based Antiretroviral Therapy Adherence Intervention (Thrive With Me) in a Community-Recruited Sample of Sexual Minority Men Living With HIV: Results of a Randomized Controlled Study.Journal of medical Internet research · 2024Trial
- Long-Term Effect of Group Support Psychotherapy on Depression and HIV Treatment Outcomes: Secondary Analysis of a Cluster Randomized Trial in Uganda.Psychosomatic medicine · 2022Trial
- Tina's ParTy line: Polysubstance use patterns in sexual minority men living with HIV who use methamphetamine.Drug and alcohol review · 2022Trial
- An autoregressive cross-lagged model unraveling co-occurring stimulant use and HIV: Results from a randomized controlled trial.Drug and alcohol dependence · 2021Trial
- Blue Monday: Co-occurring Stimulant Use and HIV Persistence Predict Dysregulated Catecholamine Synthesis.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- A Pilot Study of a Mobile App to Support HIV Antiretroviral Therapy Adherence Among Men Who Have Sex with Men Who Use Stimulants.AIDS and behavior · 2019Trial
- Pilot Randomized Controlled Trial of a Syndemics Intervention with HIV-Positive, Cocaine-Using Women.AIDS and behavior · 2019Trial
- Trial
- Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.Brain, behavior, and immunity · 2018Trial
- Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial.AIDS care · 2017Trial
- A community-engaged randomized controlled trial of an integrative intervention with HIV-positive, methamphetamine-using men who have sex with men.BMC public health · 2016Trial
- Pilot randomized controlled trial of an integrative intervention with methamphetamine-using men who have sex with men.Archives of sexual behavior · 2015Trial
- The influence of depressive symptoms on alcohol use among HIV-infected Russian drinkers.Drug and alcohol dependence · 2014Trial
- Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: a randomized controlled trial.American journal of public health · 2013Trial
- Evaluating mental health integration in PrEP programs to reduce HIV incidence among US gay and bisexual men: a network modeling study.BMC health services research · 2026Article
- Multiple Discrimination, Substance-Related Coping, and Depression Among Sexual Minority Men with HIV.Journal of homosexuality · 2026Article
- Optimizing an App-Based Just-in-Time Adaptive Intervention for Stimulant Use Among Sexual Minority Men Living with HIV: Protocol for a Community-Engaged Research Approach and Hybrid-Experimental Design.JMIR research protocols · 2025Article
- Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine.Brain, behavior, & immunity - health · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundIn the era of antiretroviral therapy (ART), depression and substance use predict hastened HIV disease progression, but the underlying biological or behavioral mechanisms that explain these effects are not fully understood.
methodsUsing outcome data from 603 participants enrolled in a randomized controlled trial of a behavioral intervention, binary logistic and linear regression were employed to examine whether inconsistent patterns of ART utilization partially mediated the effects of depression and substance use on higher HIV viral load over a 25-month follow-up.
resultsElevated affective symptoms of depression independently predicted ART discontinuation [adjusted odds ratio = 1.39, 95% confidence interval (CI) = 1.08 to 1.78], and use of stimulants at least weekly independently predicted intermittent ART utilization (adjusted odds ratio = 2.62, 95% CI = 1.45 to 4.73). After controlling for the average self-reported percentage of ART doses taken and baseline T-helper (CD4) count, elevated depressive symptoms predicted a 50% higher mean viral load, and weekly stimulant use predicted a 137% higher mean viral load. These effects became nonsignificant after accounting for inconsistent patterns of ART utilization, providing evidence of partial mediation.
conclusionsInconsistent patterns of ART utilization may partially explain the effects of depression and stimulant use on hastened HIV disease progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.