ArticleGenetics2011
A model selection approach for expression quantitative trait loci (eQTL) mapping.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- reg-eQTL: Integrating transcription factor effects to unveil regulatory variants.American journal of human genetics · 2025Article
- LORSEN: Fast and Efficient eQTL Mapping With Low Rank Penalized Regression.Frontiers in genetics · 2021Article
- Article
- Novel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping.G3 (Bethesda, Md.) · 2017Article
- A network based covariance test for detecting multivariate eQTL in saccharomyces cerevisiae.BMC systems biology · 2016Article
- Causal Genetic Inference Using Haplotypes as Instrumental Variables.Genetic epidemiology · 2016Article
- The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Finding alternative expression quantitative trait loci by exploring sparse model space.Journal of computational biology : a journal of computational molecular cell biology · 2014Article
- Causal inference of gene regulation with subnetwork assembly from genetical genomics data.Nucleic acids research · 2014Article
- eQTL Epistasis - Challenges and Computational Approaches.Frontiers in genetics · 2013Article
- Organ specificity and transcriptional control of metabolic routes revealed by expression QTL profiling of source--sink tissues in a segregating potato population.BMC plant biology · 2012Article
- Computational tools for discovery and interpretation of expression quantitative trait loci.Pharmacogenomics · 2012Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Identifying the genetic basis of complex traits remains an important and challenging problem with the potential to affect a broad range of biological endeavors. A number of statistical methods are available for mapping quantitative trait loci (QTL), but their application to high-throughput phenotypes has been limited as most require user input and interaction. Recently, methods have been developed specifically for expression QTL (eQTL) mapping, but they too are limited in that they do not allow for interactions and QTL of moderate effect. We here propose an automated model-selection-based approach that identifies multiple eQTL in experimental populations, allowing for eQTL of moderate effect and interactions. Output can be used to identify groups of transcripts that are likely coregulated, as demonstrated in a study of diabetes in mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.