Evidence map›Paper›PMID 21115865›Full record

SynthesisJournal of clinical oncology : official journal of the American Society of Clinical Oncology2011

Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.

Kimberly S Peairs, Bethany B Barone, Claire F Snyder, Hsin-Chieh Yeh, Kelly B Stein, Rachel L Derr, Frederick L Brancati, Antonio C Wolff

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 11 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 11 syntheses or guidelines pooled it, 456 citations in OpenAlex.

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  3. The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2020
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  8. Correlations Between Abnormal Glucose Metabolism and Bone Mineral Density or Bone Metabolism.Medical science monitor : international medical journal of experimental and clinical research · 2016
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171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kimberly S PeairsDivision of General Internal Medicine, Johns Hopkins University School of Medicine, 10753 Falls Rd, Suite 325, Lutherville, MD 21093, USA. kpeairs@jhmi.edu
Bethany B Barone
Claire F Snyder
Hsin-Chieh Yeh
Kelly B Stein
Rachel L Derr
Frederick L Brancati
Antonio C Wolff
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Diabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1M
Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Patient Oriented Research in Type 2 DiabetesK24DK062222 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L · 2002 to 2011
$1.7M
NIDDK NIH HHS K24 DK062222NIDDK NIH HHS K24DK062222-06NIDDK NIH HHS P60 DK079637NIDDK NIH HHS T32 DK062707PHS HHS T32HP10025-14
6 · The paper itself

Abstract

purposeThe goal of this study was to perform a systematic review and meta-analysis to examine the effect of pre-existing diabetes on breast cancer-related outcomes.

methodsWe searched EMBASE and MEDLINE databases from inception through July 1, 2009, using search terms related to diabetes mellitus, cancer, and prognostic outcome. Studies were included if they reported a prognostic outcome by diabetes status, evaluated a cancer population, and contained original data published in the English language. We performed a meta-analysis of pre-existing diabetes and its effect on all-cause mortality in patients with breast cancer and qualitatively summarized other prognostic outcomes.

resultsOf 8,828 titles identified, eight articles met inclusion/exclusion criteria and described outcomes in patients with breast cancer and diabetes. Pre-existing diabetes was significantly associated with all-cause mortality in six of seven studies. In a meta-analysis, patients with breast cancer and diabetes had a significantly higher all-cause mortality risk (pooled hazard ratio [HR], 1.49; 95% CI, 1.35 to 1.65) compared with their nondiabetic counterparts. Three of four studies found pre-existing diabetes to be associated with more advanced stage at presentation. Diabetes was also associated with altered regimens for breast cancer treatment and increased toxicity from chemotherapy.

conclusionCompared with their nondiabetic counterparts, patients with breast cancer and pre-existing diabetes have a greater risk of death and tend to present at later stages and receive altered treatment regimens. Studies are needed to investigate pathophysiologic interactions between diabetes and breast cancer and determine whether improvements in diabetes care can reduce mortality in patients with breast cancer.

Indexed as

Breast NeoplasmsDiabetes MellitusFemaleHumansInsulin ResistanceNeoplasm StagingPrognosisRisk Factors

Identifiers

PMID21115865
PMCPMC3055858
OpenAlexW2096686828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.