ArticleMolecular biology of the cell2010
The yeast vps class E mutants: the beginning of the molecular genetic analysis of multivesicular body biogenesis.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- VPS4A is the selective receptor for lipophagy in mice and humans.Molecular cell · 2024Article
- Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer.Experimental & molecular medicine · 2024Review
- Context-specific regulation of extracellular vesicle biogenesis and cargo selection.Nature reviews. Molecular cell biology · 2023Review
- Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole.Journal of cell science · 2022Article
- Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability.Molecular systems biology · 2020Article
- Rab5-dependent autophagosome closure by ESCRT.The Journal of cell biology · 2019Article
- Dividing the Archaeal Way: The Ancient Cdv Cell-Division Machinery.Frontiers in microbiology · 2018Review
- Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate.Human molecular genetics · 2017Article
- Article
- Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.The Journal of cell biology · 2015Article
- Saccharomyces cerevisiae vacuolar H+-ATPase regulation by disassembly and reassembly: one structure and multiple signals.Eukaryotic cell · 2014Review
- Ubiquitin-dependent sorting in endocytosis.Cold Spring Harbor perspectives in biology · 2014Review
- Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants.Current genetics · 2013Review
- A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting.Molecular biology of the cell · 2012Article
- Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.The EMBO journal · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
In 1992, Raymond et al. published a compilation of the 41 yeast vacuolar protein sorting (vps) mutant groups and described a large class of mutants (class E vps mutants) that accumulated an exaggerated prevacuolar endosome-like compartment. Further analysis revealed that this "class E compartment" contained soluble vacuolar hydrolases, vacuolar membrane proteins, and Golgi membrane proteins unable to recycle back to the Golgi complex, yet these class E vps mutants had what seemed to be normal vacuoles. The 13 class E VPS genes were later shown to encode the proteins that make up the complexes required for formation of intralumenal vesicles in late endosomal compartments called multivesicular bodies, and for the sorting of ubiquitinated cargo proteins into these internal vesicles for eventual delivery to the vacuole or lysosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.