ArticleProceedings of the National Academy of Sciences of the United States of America2010
Jumonji domain protein JMJD5 functions in both the plant and human circadian systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 162 citations in OpenAlex.
- Glycine max Jumonji C domain-containing proteins JMJ19/20 exhibit endopeptidase activity and interact with LUXs to mediate flowering time.Nucleic acids research · 2026Article
- JMJD5: a multifunctional regulator in development, homeostasis, and cancer.Frontiers in cell and developmental biology · 2026Review
- Dissecting usuranme biquitin-mediated circadian clock regulation in Arabidopsis via high-throughput yeast screens.Journal of experimental botany · 2025Article
- 48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis.Nature communications · 2025Article
- Nature's Master of Ceremony: TheNpj biological timing and sleep · 2025Article
- Transcriptome Analysis Reveals Genes Responsive to Three Low-Temperature Treatments inPlants (Basel, Switzerland) · 2024Article
- Histone methylation: at the crossroad between circadian rhythms in transcription and metabolism.Frontiers in genetics · 2024Review
- Lentil adaptation to drought stress: response, tolerance, and breeding approaches.Frontiers in plant science · 2024Review
- JMJD5 inhibits lung cancer progression by facilitating EGFR proteasomal degradation.Cell death & disease · 2023Article
- Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis.Biomedicines · 2023Article
- 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.Journal of medicinal chemistry · 2023Article
- Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5.RSC chemical biology · 2023Article
- JMJD5 inhibits lung cancer progression by regulating glucose metabolism through the p53/TIGAR pathway.Medical oncology (Northwood, London, England) · 2023Article
- Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans.The Journal of clinical investigation · 2023Article
- Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors.Scientific reports · 2023Article
- Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5.Scientific reports · 2022Article
- The Perennial Clock Is an Essential Timer for Seasonal Growth Events and Cold Hardiness.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Epigenetic reprogramming of H3K27me3 and DNA methylation during leaf-to-callus transition in peach.Horticulture research · 2022Article
- Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation.Journal of personalized medicine · 2021Review
39 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Circadian clocks are near-ubiquitous molecular oscillators that coordinate biochemical, physiological, and behavioral processes with environmental cues, such as dawn and dusk. Circadian timing mechanisms are thought to have arisen multiple times throughout the evolution of eukaryotes but share a similar overall structure consisting of interlocking transcriptional and posttranslational feedback loops. Recent work in both plants and animals has also linked modification of histones to circadian clock function. Now, using data from published microarray experiments, we have identified a histone demethylase, jumonji domain containing 5 (JMJD5), as a previously undescribed participant in both the human and Arabidopsis circadian systems. Arabidopsis JMJD5 is coregulated with evening-phased clock components and positively affects expression of clock genes expressed at dawn. We found that both Arabidopsis jmjd5 mutant seedlings and mammalian cell cultures deficient for the human ortholog of this gene have similar fast-running circadian oscillations compared with WT. Remarkably, both the Arabidopsis and human JMJD5 orthologs retain sufficient commonality to rescue the circadian phenotype of the reciprocal system. Thus, JMJD5 plays an interchangeable role in the timing mechanisms of plants and animals despite their highly divergent evolutionary paths.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.