ArticleProceedings of the National Academy of Sciences of the United States of America2010
Regulation of hematopoietic stem cells by their mature progeny.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Hematopoietic stem and progenitor cell hierarchy is established by thrombopoietin-driven neonatal hematopoiesis.Stem cell reports · 2026Article
- Article
- E3 ubiquitin ligase on the biological properties of hematopoietic stem cell.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels.Blood advances · 2023Article
- High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production.Nature communications · 2023Article
- Risk Factors and Outcomes of Stem Cell Mobilization Failure in Multiple Myeloma Patients.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Day -1 CD34+ Cells and Platelet Count Predict the Number of Apheresis in Poor-Mobilizer Patients Rescued by Plerixafor.Journal of clinical medicine · 2023Article
- Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation.eLife · 2021Article
- The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants.Frontiers in pediatrics · 2021Article
- Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation.Frontiers in immunology · 2020Review
- Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l.Scientific reports · 2019Article
- Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages.Bulletin of mathematical biology · 2018Article
- The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation.Experimental hematology · 2018Article
- Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.Scientific reports · 2017Article
- Lung as a Niche for Hematopoietic Progenitors.Stem cell reviews and reports · 2017Review
- Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis.Scientific reports · 2017Article
- Feedback control in planarian stem cell systems.BMC systems biology · 2016Article
- Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications.Stem cells international · 2016Review
- Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via receptor-mediated internalization and degradation. Here, we demonstrate that the megakaryocytosis and increased platelet mass in mice with mutations in the Myb or p300 genes causes reduced circulating TPO concentration and TPO starvation of the stem-cell compartment, which is exacerbated because these cells additionally exhibit impaired responsiveness to TPO. HSCs from Myb(Plt4/Plt4) mice show altered expression of TPO-responsive genes and, like HSCs from Tpo and Mpl mutant mice, exhibit increased cycling and a decline in the number of HSCs with age. These studies suggest that disorders of platelet number can have profound effects on the HSC compartment via effects on the feedback regulation of circulating TPO concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.