ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Review
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Advances in the Xenopus immunome: Diversification, expansion, and contraction.Developmental and comparative immunology · 2023Review
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- Engraftment of Allotransplanted Tumor Cells in AdultCancers · 2022Article
- γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- TheAnimals : an open access journal from MDPI · 2019Article
- Not all birds have a single dominantly expressed MHC-I gene: Transcription suggests that siskins have many highly expressed MHC-I genes.Scientific reports · 2019Article
- Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer.Immunological investigations · 2019Review
- Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus.Carcinogenesis · 2019Article
- Article
- DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses.OncoTargets and therapy · 2019Review
- Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Killer T cells show their kinder side.Nature · 2018Article
- Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions.Frontiers in immunology · 2018Review
- Exploring the functions of nonclassical MHC class Ib genes in Xenopus laevis by the CRISPR/Cas9 system.Developmental biology · 2017Article
- Tumor immunology viewed from alternative animal models-theCurrent pathobiology reports · 2017Article
- Diversity and selection of MHC class I genes in the vulnerable Chinese egret (Egretta eulophotes).PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nonclassical MHC class Ib (class Ib) genes are heterogeneous genes encoding molecules that are structurally similar to classical MHC class Ia molecules but with limited tissue distribution and polymorphism. Mammalian class Ib genes have diverse and often uncharacterized functions, and because of their rapid rate of evolution, class Ib phylogeny is difficult to establish. We have conducted an extensive genomic, molecular, and phylogenetic characterization of class Ib genes in two Xenopodinae amphibian species of different genera that diverged from a common ancestor as long ago as primates and rodents (∼65 million years). In contrast with the unsteadiness of mammalian class Ib genes, our results reveal an unusual degree of conservation of most Xenopodinae class Ib gene lineages, including a novel monogenic lineage represented by the divergent Xenopus laevis XNC10 gene and its unequivocal Silurana (Xenopus) tropicalis orthologue, SNC10. The preferential expression of this gene lineage by thymocytes themselves from the onset of thymic organogenesis is consistent with a specialized role of class Ib in early T cell development and suggests such a function is conserved in all tetrapods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.