ArticleMolecular and cellular biology2011
Spt10 and Swi4 control the timing of histone H2A/H2B gene activation in budding yeast.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients.The EMBO journal · 2024Article
- Transcription coordinates histone amounts and genome content.Nature communications · 2021Article
- A method for assessing histone surface accessibility genome-wide.Methods (San Diego, Calif.) · 2020Article
- Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span.Nucleic acids research · 2019Article
- A transcriptome-wide analysis deciphers distinct roles of G1 cyclins in temporal organization of the yeast cell cycle.Scientific reports · 2019Article
- Regulation of conidiation, dimorphic transition, and microsclerotia formation by MrSwi6 transcription factor in dimorphic fungus Metarhizium rileyi.World journal of microbiology & biotechnology · 2019Article
- Regulation of DNA replication-coupled histone gene expression.Oncotarget · 2017Review
- Regulation of cell-to-cell variability in divergent gene expression.Nature communications · 2016Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Heavy transcription of yeast genes correlates with differential loss of histone H2B relative to H4 and queued RNA polymerases.Nucleic acids research · 2014Article
- Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of histone gene transcription in yeast.Cellular and molecular life sciences : CMLS · 2014Review
- Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones.Molecular biology of the cell · 2013Article
- Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- Differential analysis of high-throughput quantitative genetic interaction data.Genome biology · 2012Article
- Direct interplay among histones, histone chaperones, and a chromatin boundary protein in the control of histone gene expression.Molecular and cellular biology · 2012Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- Chromatin and transcription in yeast.Genetics · 2012Review
- Transparent mediation-based access to multiple yeast data sources using an ontology driven interface.BMC bioinformatics · 2012Article
- The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.Biochimica et biophysica acta · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The expression of the histone genes is regulated during the cell cycle to provide histones for nucleosome assembly during DNA replication. In budding yeast, histones H2A and H2B are expressed from divergent promoters at the HTA1-HTB1 and HTA2-HTB2 loci. Here, we show that the major activator of HTA1-HTB1 is Spt10, a sequence-specific DNA binding protein with a putative histone acetyltransferase (HAT) domain. Spt10 binds to two pairs of upstream activation sequence (UAS) elements in the HTA1-HTB1 promoter: UAS1 and UAS2 drive HTA1 expression, and UAS3 and UAS4 drive HTB1 expression. UAS3 and UAS4 also contain binding sites for the cell cycle regulator SBF (an Swi4-Swi6 heterodimer), which overlap the Spt10 binding sites. The binding of Spt10 and binding of SBF to UAS3 and UAS4 are mutually exclusive in vitro. Both SBF and Spt10 are bound in cells arrested with α-factor, apparently awaiting a signal to activate transcription. Soon after the removal of α-factor, SBF initiates a small, early peak of HTA1 and HTB1 transcription, which is followed by a much larger peak due to Spt10. Both activators dissociate from the HTA1-HTB1 promoter after expression has been activated. Thus, SBF and Spt10 cooperate to control the timing of HTA1-HTB1 expression.
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