ArticleInfection and immunity2011
The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Evidence of a role for the F1 capsule ofmBio · 2025Article
- Genomic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium.Science advances · 2023Article
- Article
- PsaF Is a Membrane-Localized pH Sensor That RegulatesJournal of bacteriology · 2021Article
- Tn-Seq Analysis Identifies Genes Important for Yersinia pestis Adherence during Primary Pneumonic Plague.mSphere · 2020Article
- Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2Infection and immunity · 2020Article
- Development of Anti-ImmunoTargets and therapy · 2020Article
- Temperature Control ofJournal of bacteriology · 2019Article
- One year immunogenicity and safety of subunit plague vaccine in Chinese healthy adults: An extended open-label study.Human vaccines & immunotherapeutics · 2018Article
- Functional and structural characteristics of bacterial proteins that bind host cytokines.Virulence · 2017Review
- Article
- Plague Vaccines: Status and Future.Advances in experimental medicine and biology · 2016Review
- Comparison of Models for Bubonic Plague Reveals Unique Pathogen Adaptations to the Dermis.Infection and immunity · 2015Article
- Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination.PLoS neglected tropical diseases · 2015Article
- New insights into how Yersinia pestis adapts to its mammalian host during bubonic plague.PLoS pathogens · 2014Article
- Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae.Frontiers in cellular and infection microbiology · 2014Review
- Article
- Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis.Molecular microbiology · 2013Article
- Protecting against plague: towards a next-generation vaccine.Clinical and experimental immunology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there is a need for vaccine targets and a greater understanding of the role of these targets in pathogenesis. Two prime Y. pestis vaccine candidates are the usher-chaperone fimbriae Psa and Caf. Herein we report that Y. pestis requires, in a nonredundant manner, both PsaA and Caf1 to achieve its full pathogenic ability in both pneumonic and bubonic plague in C57BL/6J mice. Deletion of psaA leads to a decrease in the organ bacterial burden and to a significant increase in the 50% lethal dose (LD₅₀) after subcutaneous infection. Deletion of caf1 also leads to a significant decrease in the organ bacterial burden but more importantly leads to a significantly greater increase in the LD₅₀ than was observed for the ΔpsaA mutant strain after subcutaneous infection of C57BL/6J mice. Furthermore, the degree of attenuation of the Δcaf1 mutant strain is mouse background dependent, as the Δcaf1 mutant strain was attenuated to a lesser degree in BALB/cJ mice by the subcutaneous route than in C57BL/6J mice. This observation that the degree of requirement for Caf1 is dependent on the mouse background indicates that the virulence of Y. pestis is dependent on the genetic makeup of its host and provides further support for the hypothesis that PsaA and Caf1 have different targets.
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Registered trials
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