Evidence map›Paper›PMID 21115642›Full record

ArticleThe Journal of physiology2011

Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.

Charlotte L Grove, Theresa M Szabo, J Michael McIntosh, Samantha C Do, Robert F Waldeck, Donald S Faber

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Charlotte L GroveDominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. charlotte.grove@nyumc.org
Theresa M Szabo
J Michael McIntosh
Samantha C Do
Robert F Waldeck
Donald S Faber
Albert Einstein College of Medicine · USUniversity of Scranton · USUniversity of Utah · US

Funding

Venoms, Biological Resources, Molecular BiologyP01GM048677 · NIGMS · UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M · 1993 to 2018
$32.2M
TRAINING IN HORMONE-MEMBRANE INTERACTIONST32DK007513 · NIDDK · YESHIVA UNIVERSITY · PI ZUKIN, R. SUZANNE · 1986 to 2011
$3.7M
Novel Neuronal nAChR-Targeted PeptidesR01MH053631 · NIMH · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2001 to 2011
$3.6M
NOVEL NEURONAL NACHR-TARGETED PEPTIDESR29MH053631 · NIMH · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 1996 to 2000
$107k
REGULATION OF TRANSMITTER RELEASE AT CENTRAL SYNAPSESR01NS021848 · NINDS · YESHIVA UNIVERSITY · PI FABER, DONALD S · 1986 to 1999
–
NIDDK NIH HHS T32 DK007513NIDDK NIH HHS T32DK075-13-17NIGMS NIH HHS GM48677NIGMS NIH HHS P01 GM048677NIMH NIH HHS MH53631NIMH NIH HHS R01 MH053631NIMH NIH HHS R29 MH053631NINDS NIH HHS NS21848
6 · The paper itself

Abstract

Usually nicotinic receptors in the central nervous system only influence the strength of a signal between neurons. At a few critical connections, for instance some of those involved in the flight response, nicotinic receptors not only modulate the signal, they actually determine whether a signal is conveyed or not. We show at one of the few such connections accessible for study, up to three different nicotinic receptor subtypes mediate the signal. The subtypes appear to be clustered in separate locations. Depending on the number and combination of the subtypes present the signal can range from short to long duration and from low to high amplitude. This provides a critical connection with a built-in plasticity and may enable it to adapt to a changing environment.

Indexed as

Aconitinealpha7 Nicotinic Acetylcholine ReceptorAnimalsAxonsBungarotoxinsCentral Nervous SystemConotoxinsDihydro-beta-ErythroidineElectric StimulationExcitatory Postsynaptic PotentialsGoldfishHumansKineticsMaleNeuronsNicotinic AntagonistsAconitinealpha7 Nicotinic Acetylcholine ReceptorBungarotoxinsChrna7 protein, humanConotoxinsDihydro-beta-ErythroidinemethyllycaconitineNicotinic Antagonistsnicotinic receptor alpha3beta2nicotinic receptor alpha3beta4Receptors, Nicotinic

Identifiers

PMID21115642
PMCPMC3055544
OpenAlexW2150299185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.