ArticleClinical journal of the American Society of Nephrology : CJASN2011
Which creatinine and cystatin C equations can be reliably used in children?
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Estimated versus measured glomerular filtration rate in children before hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014Trial
- Correlation Between Renal Biomarkers, Glomerular Filtration Rate, and Meropenem Clearance in Pediatric Septic Shock.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Retinal vascular density in children with hypertension.Pediatric nephrology (Berlin, Germany) · 2026Article
- Comparison of estimated and measured GFR in pediatric CKD patients transitioning from adolescence to adulthood: results from KNOW-PedCKD.BMC nephrology · 2026Article
- Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia.Paediatric drugs · 2025Article
- Continuous frusemide infusion versus intermittent bolus therapy in paediatric intensive care: A single centre retrospective study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning.European journal of clinical pharmacology · 2024Article
- Cystatin C as a Marker of Kidney Function in Children.Biomolecules · 2024Review
- Kidney Measurement and Glomerular Filtration Rate Evolution in Children with Polycystic Kidney Disease.Children (Basel, Switzerland) · 2024Article
- Association of albuminuria with kidney function and hemodynamic disturbance in pre-school children who undergo congenital heart disease surgery.Pediatric nephrology (Berlin, Germany) · 2024Article
- Childhood Obesity: Insight into Kidney Involvement.International journal of molecular sciences · 2023Review
- Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.BMC nephrology · 2023Article
- ESTIMATION OF THE GLOMERULAR FILTRATION RATE IN CHILDREN WITH HEMOPHILIA.Acta clinica Croatica · 2022Article
- Agreement between serum estimates of glomerular filtration rate (GFR) and a reference standard of radioisotopic GFR in children with cancer.Pediatric radiology · 2022Article
- Persistent Markers of Kidney Injury in Children Who Developed Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Cohort Study.Journal of the American Heart Association · 2022Article
- Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.Diabetes care · 2021Article
- Differences between Obese and Non-Obese Children and Adolescents Regarding Their Oral Status and Blood Markers of Kidney Diseases.Journal of clinical medicine · 2021Article
- Renal insufficiency in children born preterm: examining the role of neonatal acute kidney injury.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Estimated glomerular filtration rate in children: adapting existing equations for a specific population.Pediatric nephrology (Berlin, Germany) · 2021Article
- Prenatal alcohol exposure affects renal function in overweight schoolchildren: birth cohort analysis.Pediatric nephrology (Berlin, Germany) · 2020Article
13 more citing papers are in PubMed but not listed here.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEstimation of GFR in children is challenging; reference methods are cumbersome, and formulas have limitations. The aims of this study were to evaluate (1) the new creatinine-based formula recently proposed by Schwartz using a kinetic colorimetric compensated Jaffe technique; (2) some cystatin C-derived formulas (Hoek, Le Bricon, Larsson, Rule, Filler, and Zappitelli) using a nephelemetric technique; and (3) combined formulas using both cystatin and creatinine (Zappitelli and Bouvet). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: These formulas were evaluated in a cross-sectional cohort of 252 children with moderate CKD or normal GFR, in comparison with the reference standard (inulin clearance, iGFR). Mean age, body weight, height, creatinine, and cystatin C were 10.7 ± 4.0 years, 35 ± 15 kg, 137 ± 20 cm, 55 ± 30 μmol/L, and 0.91 ± 0.35 mg/L, respectively.
resultsMean ± SD iGFR was 101 ± 32 ml/min per 1.73 m². When evaluating agreement between these formulas and iGFR (e.g. correlation, Bland Altman plots, bias, and accuracies), there was a good correlation between iGFR and all Le Bricon, Larsson, Rule, and Zappitelli (both) and locally adapted Schwartz and 2009 Schwartz formulas; by contrast, Filler and original 1976 Schwartz formulas overestimated iGFR, whereas Hoek and Bouvet formulas underestimated iGFR.
conclusionDifferent cystatin C-derived formulas (at least Larsson and Le Bricon) for estimating GFR as well as the Zappitelli combined formula are accurate in addition to the new Schwartz bedside formula in a general pediatric population.
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