ArticleClinical journal of the American Society of Nephrology : CJASN2011
Implications of the CKD-EPI GFR estimation equation in clinical practice.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Creatinine-or cystatin C-based equations to estimate glomerular filtration in the general population: impact on the epidemiology of chronic kidney disease.BMC nephrology · 2013Trial
- Efficacy and Safety of Finerenone Combined with Dapagliflozin in the Treatment of Non-Diabetic Chronic Kidney Disease: A Single-Center Retrospective Study.Drug design, development and therapy · 2026Article
- Possible Use of the SUDOSCAN Nephropathy Risk Score in Chronic Kidney Disease Diagnosis: Application in Patients with Type 2 Diabetes.Biosensors · 2025Article
- Estimated glomerular filtration rate and the risk of stroke in individuals with diabetes mellitus and atrial fibrillation insight from a large contemporary population study.Journal of thrombosis and thrombolysis · 2024Article
- Model-informed precision dosing in vancomycin treatment.Frontiers in pharmacology · 2023Article
- Using race in the estimation of glomerular filtration rates: time for a reversal?Current opinion in nephrology and hypertension · 2020Review
- Impact of a single eGFR and eGFR-estimating equation on chronic kidney disease reclassification: a cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- The Impact of Admission Serum Creatinine on Major Adverse Clinical Events in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.Cardiology research · 2018Article
- SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes.Experimental and therapeutic medicine · 2017Article
- Increased risk of cardiovascular events in end-stage renal disease patients with osteoporosis: a nationwide population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Article
- Electronic health records: a new tool to combat chronic kidney disease?Clinical nephrology · 2013Article
- GFR estimation in the morbidly obese pre- and postbariatric surgery: one size does not fit all.International urology and nephrology · 2013Article
- The prevalence of chronic kidney disease in the general population in Romania: a study on 60,000 persons.International urology and nephrology · 2012Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesChronic kidney disease (CKD) is a significant public health problem whose diagnosis and staging relies upon GFR-estimating equations, including the new CKD-EPI equation. CKD-EPI demonstrated superior performance compared with the existing MDRD equation but has not been applied to a healthcare system. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We identified 53,759 patients with stages 3 to 5 CKD on the basis of either MDRD or CKD-EPI equations using two eGFR values <60 ml/min per 1.73 m² > 90 days apart from an outpatient setting. We compared patient characteristics, presence of related diagnosis codes, and time CKD classification between equations.
resultsThe number of patients identified with CKD decreased 10% applying CKD-EPI versus MDRD. Changes varied substantially by patient characteristics including a 35% decrease among patients < 60 years and a 10% increase among patients > 90 years. Women, non-African Americans, nondiabetics, and obese patients were less likely to be classified on the basis of CKD-EPI. Time to CKD classification was significantly longer with CKD-EPI among younger patients. 14% of patients identified with CKD on the basis of either estimating equation also had a related ICD-9 diagnosis, ranging from 19% among patients < 60 years to 7% among patients > 90 years.
conclusionsConsistent with findings in the general population, CKD-EPI resulted in substantial declines in equation-based CKD diagnoses in a large healthcare system. Further research is needed to determine whether widespread use of CKD-EPI with current guidelines could lead to delayed needed care among younger patients or excessive referrals among older patients.
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