ArticleBest practice & research. Clinical endocrinology & metabolism2010
Carney complex and other conditions associated with micronodular adrenal hyperplasias.
Article in Best practice & research. Clinical endocrinology & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Circadian Plasma Cortisol Measurements Reflect Severity of Hypercortisolemia in Children with Different Etiologies of Endogenous Cushing Syndrome.Hormone research in paediatrics · 2017Trial
- Infertility as a possible diagnostic feature of Carney complex.JCEM case reports · 2026Article
- Preventing Cushing Syndrome: Adrenalectomy inJCEM case reports · 2026Article
- cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Frontiers in endocrinology · 2026Review
- Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance.ACS omega · 2025Article
- Perioperative Care of a Patient With Carney Complex.Cardiology research · 2025Article
- Severe osteoporosis in a young man with bilateral Cushing's syndrome: a case report.Journal of medical case reports · 2023Article
- CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells.Science advances · 2023Article
- Point-of-Care Ultrasound Diagnosis of a Giant Left Atrial Mass.CASE (Philadelphia, Pa.) · 2022Article
- Adrenal hyperplasias in childhood: An update.Frontiers in endocrinology · 2022Review
- Disorders of the adrenal cortex: Genetic and molecular aspects.Frontiers in endocrinology · 2022Review
- Macronodular adrenal hyperplasia masquerading as an upper pole renal mass.Urology case reports · 2021Article
- Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer.Journal of Cancer · 2021Article
- Recurrent cardiac and skin myxomas along with acromegaly: A case report of carney complex.ARYA atherosclerosis · 2020Article
- Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report.Frontiers in endocrinology · 2020Article
- Cushing's Syndrome in Pediatrics: An Update.Endocrinology and metabolism clinics of North America · 2018Review
- Article
- Carney Complex: A Rare Case of Multicentric Cardiac Myxoma Associated with Endocrinopathy.Case reports in cardiology · 2018Article
- The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity.Frontiers in medicine · 2018Review
- Harvey Cushing Treated the First Known Patient With Carney Complex.Journal of the Endocrine Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Carney complex (CNC) is a multiple neoplasia syndrome that is inherited in an autosomal dominant manner and is characterized by skin tumors and pigmented lesions, myxomas, schwannomas, and various endocrine tumors. Inactivating mutations of the PRKAR1A gene coding for the regulatory type I-α (RIα) subunit of protein kinase A (PKA) are responsible for the disease in most CNC patients. The overall penetrance of CNC among PRKAR1A mutation carriers is near 98%. Most PRKAR1A mutations result in premature stop codon generation and lead to nonsense-mediated mRNA decay. CNC is genetically and clinically heterogeneous, with specific mutations providing some genotype-phenotype correlation. Phosphodiesterase-11A (the PDE11A gene) and -8B (the PDE8B gene) mutations were found in patients with isolated adrenal hyperplasia and Cushing syndrome, as well in patients with PPNAD. Recent evidences demonstrated that dysregulation of cAMP/PKA pathway can modulate other signaling pathways and contributes to adrenocortical tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.