ArticleOsteoarthritis and cartilage2011
Intrinsic repair of full-thickness articular cartilage defects in the axolotl salamander.
Article in Osteoarthritis and cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The salamander limb: a perfect model to understand imperfect integration during skeletal regeneration.Biology open · 2024Review
- Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair.Bioactive materials · 2023Review
- Bone Healing Process of a Multiple Humeral Fracture in aAnimals : an open access journal from MDPI · 2023Article
- Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.Nature communications · 2022Article
- The specialist in regeneration-the Axolotl-a suitable model to study bone healing?NPJ Regenerative medicine · 2022Article
- Article
- Differential Gene Expression in Articular Cartilage and Subchondral Bone of Neonatal and Adult Horses.Genes · 2019Article
- Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences.Current topics in developmental biology · 2019Review
- Changes in the appendicular skeleton during metamorphosis in the axolotl salamander (Ambystoma mexicanum).Journal of anatomy · 2018Article
- A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography.Scientific reports · 2018Article
- Non-invasive cell tracking of SPIO labeled cells in an intrinsic regenerative environment: The axolotl limb.Experimental and therapeutic medicine · 2018Article
- Article
- A silk fibroin/chitosan scaffold in combination with bone marrow-derived mesenchymal stem cells to repair cartilage defects in the rabbit knee.Journal of materials science. Materials in medicine · 2013Article
- Structural and functional analysis of intra-articular interzone tissue in axolotl salamanders.Osteoarthritis and cartilage · 2012Article
- Article
- Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects.JB & JS open accessArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe ability to fully regenerate lost limbs has made the axolotl salamander (Ambystoma mexicanum) a valuable model for studies of tissue regeneration. The current experiments investigate the ability of these vertebrates to repair large articular cartilage defects and restore normal hyaline cartilage and joint structure independent of limb amputation.
methodsFull-thickness articular cartilage defects were made by resection of the medial femoral condyle to the level of the metaphysis. At 0, 2 days, 1, 2, 3, 4, 6, 8, 12, 18, 24, 36 and 48 weeks post-surgery, the repair process was analyzed on H&E and Safranin-O stained 7 μm tissue sections. Symmetric Kullback-Leibler (SKL) divergences were used to assess proteoglycan staining intensities. Immunohistochemistry was performed for collagen types I and II.
resultsA fibrous "interzone-like" tissue occupies the intraarticular space of the axolotl femorotibial joint and no evidence of joint cavitation was observed. By 4 weeks post-surgery, cells within the defect site exhibited morphological similarities to those of the interzone-like tissue. At 24 weeks, joint structure and cartilaginous tissue repair were confirmed by immunohistochemistry for collagen types I and II. Quantitation of Safranin-O staining indicated restoration of proteoglycan content by 18 weeks.
conclusionsThe axolotl femorotibial joint has morphological similarities to the developing mammalian diarthrodial joint. Cells in the intraarticular space may be homologous to the interzone tissue and contribute to intrinsic repair of full-thickness articular cartilage defects. Taken together, these results suggest that the axolotl may serve as a valuable model for the investigation of cellular and molecular mechanisms that achieve full articular cartilage repair.
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