ArticleCritical care (London, England)2010
No agreement of mixed venous and central venous saturation in sepsis, independent of sepsis origin.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Foundations and Advancements in Hemodynamic Monitoring: Part I-Elements of HemodynamicsTurkish journal of anaesthesiology and reanimation · 2025Article
- Observational
- Blood gas analysis as a surrogate for microhemodynamic monitoring in sepsis.World journal of emergency medicine · 2023Review
- The Impact of Red Blood Cell Transfusion on Blood Lactate in Non-Bleeding Critically Ill Patients-A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Physiologic approach to red blood cell transfusion in non-bleeding critically ill patients.Archives of medical science : AMS · 2022Article
- Improving the prognostic value of ∆PCOJournal of clinical monitoring and computing · 2020Article
- [Venous saturation : Between oxygen delivery and consumption].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock.World journal of critical care medicine · 2016Review
- Venous-to-arterial carbon dioxide differences and the microcirculation in sepsis.Annals of translational medicine · 2016Article
- Evaluation of a computer program for non-invasive determination of pulmonary shunt and ventilation-perfusion mismatch.Journal of clinical monitoring and computing · 2014Article
- Central venous oxygenation: when physiology explains apparent discrepancies.Critical care (London, England) · 2014Review
- The multimodal concept of hemodynamic stabilization.Frontiers in public health · 2014Review
- Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.Critical care (London, England) · 2013Observational
- Central venous-arterial pCO₂ difference as a tool in resuscitation of septic patients.Intensive care medicine · 2013Article
- Clinical review: What are the best hemodynamic targets for noncardiac surgical patients?Critical care (London, England) · 2013Review
- Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle.Critical care (London, England) · 2011Review
- ICU survival and the central to mixed venous oxygen difference.Critical care (London, England) · 2011Article
- Year in review 2010: Critical Care--Cardiology.Critical care (London, England) · 2011Review
- What's New in Critical Illness and Injury Science? Utility of central venous oxygen saturation to risk stratify septic patients.International journal of critical illness and injury scienceArticle
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionControversy remains regarding the relationship between central venous saturation (ScvO(2)) and mixed venous saturation (SvO(2)) and their use and interchangeability in patients with sepsis or septic shock. We tested the hypothesis that ScvO(2) does not reliably predict SvO(2) in sepsis. Additionally we looked at the influence of the source (splanchnic or non-splanchnic) of sepsis on this relationship.
methodsIn this prospective observational two-center study we concurrently determined ScvO(2) and SvO(2) in a group of 53 patients with severe sepsis during the first 24 hours after admission to the intensive care units in 2 Dutch hospitals. We assessed correlation and agreement of ScvO(2) and SvO(2), including the difference, i.e. the gradient, between ScvO(2) and SvO(2) (ScvO(2) - SvO(2)). Additionally, we compared the mean differences between ScvO(2) and SvO(2) of both splanchnic and non-splanchnic group.
resultsA total of 265 paired blood samples were obtained. ScvO(2) overestimated SvO(2) by less than 5% with wide limits of agreement. For changes in ScvO(2) and SvO(2) results were similar. The distribution of the (ScvO(2) - SvO(2)) (< 0 or ≥ 0) was similar in survivors and nonsurvivors. The mean (ScvO(2) - SvO(2)) in the splanchnic group was similar to the mean (ScvO(2) - SvO(2)) in the non-splanchnic group (0.8 ± 3.9% vs. 2.5 ± 6.2%; P = 0.30). O(2)ER (P = 0.23) and its predictive value for outcome (P = 0.20) were similar in both groups.
conclusionsScvO(2) does not reliably predict SvO(2) in patients with severe sepsis. The trend of ScvO(2) is not superior to the absolute value in this context. A positive difference (ScvO(2) - SvO(2)) is not associated with improved outcome.
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