Evidence map›Paper›PMID 21114692›Full record

ArticleJournal of internal medicine2011

Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study.

O Ahlehoff, G H Gislason, M Charlot, C H Jørgensen, J Lindhardsen, J B Olesen, S Z Abildstrøm, L Skov, C Torp-Pedersen, P R Hansen

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of internal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04950218 (PSOCADIA), which is not on this map. Cited by 143 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 12 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04950218 recruitingnot on this mapstarted 2021, after this paper: background citation

PSOCADIA: Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis

TypeobservationalSponsorHerlev and Gentofte HospitalRan2021 to 2034Enrolled1,000ConditionsPsoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 12 syntheses or guidelines pooled it, 436 citations in OpenAlex.

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  3. Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
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  20. Discontinuation of Oral Anticoagulation After Successful Atrial Fibrillation Ablation - Are We Ready to Change Clinical Practice in 2026?Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

O AhlehoffDepartment of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark. olahha01@geh.regionh.dk
G H Gislason
M Charlot
C H Jørgensen
J Lindhardsen
J B Olesen
S Z Abildstrøm
L Skov
C Torp-Pedersen
P R Hansen
Gentofte Hospital · DKBispebjerg Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe magnitude of the cardiovascular risk from psoriasis and psoriatic arthritis is debated. We therefore investigated the psoriasis-related risk of adverse cardiovascular events and mortality. DESIGN, SETTING AND SUBJECTS: We conducted a cohort study of the entire Danish population aged ≥18 years followed from 1997 to 2006 by individual-level linkage of nationwide registers. Psoriasis was defined by prescription claims and classified as severe if patients received hospital-based treatment. Time-dependent Poisson regression models were applied to assess cardiovascular risk in patients with psoriasis and psoriatic arthritis.

main outcome measuresAll-cause mortality, cardiovascular mortality and hospitalizations for myocardial infarction (MI), stroke and coronary revascularization were recorded.

resultsA total of 34 371 patients with mild psoriasis and 2621 with severe psoriasis, including 607 with psoriatic arthritis, were identified and compared with 4 003 265 controls. The event rates and rate ratios (RRs) of all-cause mortality, cardiovascular death, MI, coronary revascularization, stroke and a composite of MI, stroke and cardiovascular death were increased in patients with psoriasis. The rate ratio increased with disease severity and decreased with age of onset. The overall RRs for the composite endpoint were 1.20 (95% confidence interval [CI] 1.14-1.25) and 1.58 (95% CI 1.36-1.82) for mild and severe psoriasis, respectively. The corresponding RRs for cardiovascular death were 1.14 (95% CI 1.06-1.22) and 1.57 (95% CI1.27-1.94). The risk was similar in patients with severe skin affection alone and those with psoriatic arthritis.

conclusionsPsoriasis is associated with increased risk of adverse cardiovascular events and all-cause mortality. Young age, severe skin affection and/or psoriatic arthritis carry the most risk. Patients with psoriasis may be candidates for early cardiovascular risk factor modification.

Indexed as

AdultAgedArthritis, PsoriaticCardiovascular DiseasesCause of DeathCohort StudiesDenmarkFemaleHumansMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPsoriasisRegression AnalysisRisk Factors

Identifiers

PMID21114692
OpenAlexW1599017652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.