ReviewAnnals of the New York Academy of Sciences2011
Why do T cells express the vitamin D receptor?
Review in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.Inflammatory bowel diseases · 2015Pooled it
- The effects of two vitamin D regimens on ulcerative colitis activity index, quality of life and oxidant/anti-oxidant status.Nutrition journal · 2019Trial
- Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer.Cancer discovery · 2026Article
- The Anti-Inflammatory Roles of Vitamin D for Improving Human Health.Current issues in molecular biology · 2024Review
- Vitamin D Levels as a Potential Modifier of Eosinophilic Esophagitis Severity in Adults.Digestive diseases and sciences · 2024Article
- Physiological Evidence and Therapeutic Outcomes of Vitamin D on Cardiovascular Diseases.Current cardiology reviews · 2024Review
- Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.Cancers · 2023Article
- The intestinal microenvironment shapes macrophage and dendritic cell identity and function.Immunology letters · 2023Review
- Effects ofNutrition research and practice · 2021Article
- Role of vitamin D in regulating COVID-19 severity-An immunological perspective.Journal of leukocyte biology · 2021Review
- Vitamin D and Glomerulonephritis.Medicina (Kaunas, Lithuania) · 2021Review
- Article
- Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?Journal of clinical medicine · 2020Article
- Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis.Middle East journal of digestive diseases · 2019Article
- Observational
- Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis.Digestive diseases and sciences · 2019Review
- Effects of Vitamin D Supplementation in Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.International journal of preventive medicine · 2019Article
- Vitamin D Axis in Inflammatory Bowel Diseases: Role, Current Uses and Future Perspectives.International journal of molecular sciences · 2017Review
- Age, serum 25-hydroxyvitamin D and vitamin D receptor (VDR) expression and function in peripheral blood mononuclear cells.Oncotarget · 2016Article
- CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.Digestive diseases and sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Vitamin D is an important regulator of immune function. T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets. Why should T cells be responsive to vitamin D? The data suggest that expression of the VDR is required for the development of two cell types, NKT cells and CD8αα T cells, which inhibit autoimmunity. In addition, effector T cell cytokine production is regulated by vitamin D. Available evidence suggests that NKT and CD8αα T cells express the VDR as part of the selection process to protect against the generation of autoimmunity, particularly in the gut.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.