Evidence map›Paper›PMID 21113933›Full record

ArticleEnvironmental and molecular mutagenesis2011

A study of DNA damage recognition and repair gene polymorphisms in relation to cancer predisposition and G2 chromosomal radiosensitivity.

Gillian B Curwen, Samantha Murphy, Elizabeth J Tawn, Jeanette F Winther, John D Boice

Abstract read
In one paragraph

Article in Environmental and molecular mutagenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gillian B CurwenWestlakes Research Institute, Westlakes Science and Technology Park, Moor Row, Cumbria, CA24 3LN, United Kingdom. gillian.curwen@gmail.com
Samantha Murphy
Elizabeth J Tawn
Jeanette F Winther
John D Boice

Funding

Genetic Consequences of Therapies for CancerR01CA104666 · NCI · VANDERBILT UNIVERSITY · PI BOICE, JOHN DUNNING · 2005 to 2009
$3.0M
NCI NIH HHS 1 R01 CA 104666NCI NIH HHS R01 CA104666
6 · The paper itself

Abstract

The previously reported association of the APEX Asp148Glu single nucleotide polymorphism (SNP) with cancer, and the suggestion of associations of the XRCC3 Thr241Met and hOGG1 Ser326Cys SNP sites with G(2) chromosomal radiosensitivity were investigated in a new study of 30 childhood and young adult cancer survivors, their 30 partners, and 55 offspring. An additional SNP, hOGG1 Arg46Gln was also analyzed. Data on G(2) chromosomal radiosensitivity was available on 29 of the families including 53 offspring. No significant associations of genotype with cancer or G(2) chromosomal radiosensitivity were observed.

Indexed as

Chromosome AberrationsDNA-Binding ProteinsDNA DamageDNA GlycosylasesGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansNeoplasmsPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideX-RaysDNA-Binding ProteinsDNA Glycosylasesoxoguanine glycosylase 1, humanX-ray repair cross complementing protein 3

Identifiers

PMID21113933
PMCPMC3779426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.