ArticleMolecular biology reports2011
The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Glucocorticoid receptor gene polymorphisms and glucocorticoid resistance in inflammatory bowel disease: a meta-analysis.Digestive diseases and sciences · 2012Pooled it
- New insights into the regulation of TGF-β/Smad and MPK signaling pathway gene expressions by nasal allergen and methacholine challenge test in asthma.Clinical and translational allergy · 2022Article
- Cytokine TGFβ Gene Polymorphism in Asthma: TGF-Related SNP Analysis Enhances the Prediction of Disease Diagnosis (A Case-Control Study With Multivariable Data-Mining Model Development).Frontiers in immunology · 2022Article
- TGF-β gene polimorphisms as risk factors for asthma control among clinic patients.Journal of inflammation (London, England) · 2021Article
- Pharmacogenomic Response of Inhaled Corticosteroids for the Treatment of Asthma: Considerations for Therapy.Pharmacogenomics and personalized medicine · 2020Review
- Different Gene Expressions of Alpha and Beta Glucocorticoid Receptors in Asthmatics.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Article
- Status of M1 and M2 type macrophages in keloid.International journal of clinical and experimental pathology · 2017Article
- The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients.Inflammation · 2015Article
- Influence of glucocorticoid receptor gene NR3C1 646 C>G polymorphism on glucocorticoid resistance in asthmatics: a preliminary study.Central-European journal of immunology · 2015Article
- Association analysis of the glucocorticoid receptor gene (Experimental and therapeutic medicine · 2014Article
- Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes.Experimental and therapeutic medicine · 2013Article
- Identification and association of TGFβ-1 expression in patients with asthma in a Polish population - Lodz metropolitan area study.International journal of biochemistry and molecular biology · 2013Article
- Integrative systems biology approaches in asthma pharmacogenomics.Pharmacogenomics · 2012Review
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Bcl I in the promoter polymorphism observed within h-GR/NR3C1 gene may play an important role in the development of bronchial asthma and resistance to GCs in the severe bronchial asthma. The aim of the investigation was to study the correlation between this h-GR/NR3C1 gene polymorphism and occurrence of asthma in the population of Polish asthmatics. Peripheral blood was obtained from 70 healthy volunteers and 59 asthma patients. Structuralized anamnesis, spirometry and allergy skin prick tests were performed in all participants. Genotyping was carried out with PCR-RFLP method. In healthy, non-atopic population variants of Bcl I: GG, GC, CC were found with frequency 0.129/0.471/0.400, respectively. In asthma patients Bcl I: GG, GC, CC occurred with respective frequencies of 0.410/0.462/0.128. Chi-square analysis revealed a significantly different (P<0.05) distribution between cases and controls for the Bcl I polymorphism. The Bcl I polymorphism of h-GR/NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of severe form and resistance to GCs in Polish population.
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