ArticleMolecular biology reports2011
Association between N142D genetic polymorphism of GSTO2 and susceptibility to colorectal cancer.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Glutathione Transferases Omega-1 and -2 Polymorphisms in Cancer: Drivers or Silent Bystanders?International journal of molecular sciences · 2025Pooled it
- Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies.Scientific reports · 2014Pooled it
- A meta-analysis of the relationship between glutathione S-transferases gene polymorphism and hepatocellular carcinoma in Asian population.Molecular biology reports · 2012Pooled it
- The Polymorphisms inLife (Basel, Switzerland) · 2023Article
- The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis.Journal of oncology · 2023Article
- Proteomics analysis of colon cancer progression.Clinical proteomics · 2019Article
- Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver.International journal of organ transplantation medicine · 2016Article
- Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.World journal of gastroenterology · 2015Article
- GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder.International urology and nephrology · 2015Article
- Influence of GSTO2 (N142D) genetic polymorphism on acute renal rejection.Molecular biology reports · 2013Article
- Glutathione S-transferase Omega 2 Genetic Polymorphism and Risk of Hepatic Failure that Lead to Liver Transplantation in Iranian Population.International journal of organ transplantation medicine · 2013Article
- Association of glutathione S-transferase omega gene polymorphisms with progression of head and neck cancer.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression pattern analysis has been revealed that glutathione S-transferase omega 2 (GSTO2, a member of class omega) is ubiquitously expressed. Over expression of GSTO2 induced apoptosis. The gene encoding GSTO2 was localized to human chromosome 10q24.3, a region that may harbor gene(s) involved in the developing of colorectal cancer. To investigate the association between GSTO2 N142D genetic polymorphism and susceptibility to colorectal cancer the present study was done. We studied 63 (26 females, 37 males) colorectal cancer patients and 126 (52 females, 74 males) healthy individuals. The control subjects were frequency matched for age and gender with the colorectal cancer group. The genotypes were performed using RFLP-PCR method. The ND and DD genotypes were not associated with risk of colorectal cancer, in comparison with the NN genotype. Family history for cancer in the first degree of relatives significantly differed between cases and controls (P = 0.012). The profiles of GSTO2 genotypes and family history in control and cancerous groups were compared to each other. Subjects with NN genotype and positive family history significantly were at high risk to develop colorectal cancer in comparison with subjects with DD or ND genotypes and negative family history (P = 0.003). Present findings indicating that GSTO2 NN genotype increase the risk of colorectal cancer in persons with positive family history for cancer in the first degree relatives.
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