ArticleMammalian genome : official journal of the International Mammalian Genome Society2010
Multiple loci contribute to genome-wide recombination levels in male mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Genetics of recombination rate variation within and between species.Journal of evolutionary biology · 2025Article
- Article
- Genetic background affects the strength of crossover interference in house mice.bioRxiv : the preprint server for biology · 2024Article
- Genetic variation in recombination rate in the pig.Genetics, selection, evolution : GSE · 2021Article
- Article
- Molecular evolution of the meiotic recombination pathway in mammals.Evolution; international journal of organic evolution · 2019Article
- A first genetic portrait of synaptonemal complex variation.PLoS genetics · 2019Article
- Connecting theory and data to understand recombination rate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island.Genetics · 2017Article
- Article
- Recombination rate variation in mice from an isolated island.Molecular ecology · 2017Article
- Article
- Genetic Links between Recombination and Speciation.PLoS genetics · 2016Article
- Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse.PLoS genetics · 2016Article
- Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice.Biology of reproduction · 2015Article
- Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.PLoS genetics · 2015Article
- TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.EMBO molecular medicine · 2015Article
- Article
- Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult.PLoS genetics · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Recent linkage-based studies in humans suggest the presence of loci that affect either genome-wide recombination rates, utilization of recombination hotspots, or both. We have been interested in utilizing cytological methodology to directly assess recombination in mammalian meiocytes and to identify recombination-associated loci. In the present report we summarize studies in which we combined a cytological assay of recombination in mouse pachytene spermatocytes with QTL analyses to identify loci that contribute to genome-wide levels of recombination in male meiosis. Specifically, we analyzed MLH1 foci, a marker of crossovers, in 194 F2 male mice derived from a subspecific cross between CAST/EiJ and C57BL/6J parental strains. We then used these data to uncover loci associated with individual variation in mean MLH1 values. We identified seven recombination-associated loci across the genome (on chromosomes 2, 3, 4, 14, 15, 17, and X), indicating that there are multiple recombination "setting" loci in mammalian male meiosis.
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