ReviewCurrent genetics2011
Advancing our understanding of functional genome organisation through studies in the fission yeast.
Review in Current genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Advanced Protocol for Molecular Characterization of Viral Genome in Fission Yeast (Pathogens (Basel, Switzerland) · 2024Article
- Article
- The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.International journal of molecular sciences · 2021Article
- Assembly of Schizosaccharomyces cryophilus chromosomes and their comparative genomic analyses revealed principles of genome evolution of the haploid fission yeasts.Scientific reports · 2018Article
- The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast.PloS one · 2018Article
- The functions of the multi-tasking Pfh1Current genetics · 2017Review
- Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A fission yeast cell-based system for multidrug resistant HIV-1 proteases.Cell & bioscience · 2017Article
- Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.Nucleus (Austin, Tex.) · 2016Review
- Article
- Deletion of Genes Encoding Arginase Improves Use of "Heavy" Isotope-Labeled Arginine for Mass Spectrometry in Fission Yeast.PloS one · 2015Article
- Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.Nucleic acids research · 2014Article
- Mechanisms and principles of homology search during recombination.Nature reviews. Molecular cell biology · 2014Review
- Identification and refinement of two strong constitutive promoters for gene expression system of Schizosaccharomyces pombe.World journal of microbiology & biotechnology · 2014Article
- Article
- The links between chromatin spatial organization and biological function.Biochemical Society transactions · 2013Review
- Genomic positions of co-expressed genes: echoes of chromosome organisation in gene expression data.BMC research notes · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant progress has been made in understanding the functional organisation of the cell nucleus. Still many questions remain to be answered about the relationship between the spatial organisation of the nucleus and the regulation of the genome function. There are many conflicting data in the field making it very difficult to merge published results on mammalian cells into one model on subnuclear chromatin organisation. The fission yeast, Schizosaccharomyces pombe, over the last decades has emerged as a valuable model organism in understanding basic biological mechanisms, especially the cell cycle and chromosome biology. In this review we describe and compare the nuclear organisation in mammalian and fission yeast cells. We believe that fission yeast is a good tool to resolve at least some of the contradictions and unanswered questions concerning functional nuclear architecture, since S. pombe has chromosomes structurally similar to that of human. S. pombe also has the advantage over higher eukaryotes in that the genome can easily be manipulated via homologous recombination making it possible to integrate the tools needed for visualisation of chromosomes using live-cell microscopy. Classical genetic experiments can be used to elucidate what factors are involved in a certain mechanism. The knowledge we have gained during the last few years indicates similarities between the genome organisation in fission yeast and mammalian cells. We therefore propose the use of fission yeast for further advancement of our understanding of functional nuclear organisation.
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