Evidence map›Paper›PMID 21113437›Full record

ArticleThe Journal of organic chemistry2010

Two-Steps Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides.

Adel Nefzi, Sergey Arutyunyan, Jason E Fenwick

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adel NefziTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987.
Sergey Arutyunyan
Jason E Fenwick

Funding

Stereochemically /Structurally Diverse Pilot Scale LibraP41GM079590 · NIGMS · TORREY PINES INST FOR MOLECULAR STUDIES · PI HOUGHTEN, RICHARD ALLEN · 2006 to 2009
$1.5M
Highly Diverse and Structurally Varied Heterocyclic Libraries for the MLSMRP41GM081261 · NIGMS · TORREY PINES INST FOR MOLECULAR STUDIES · PI HOUGHTEN, RICHARD ALLEN · 2007 to 2009
$1.4M
Innovative approaches to oligoheterocyclic peptidomimeticsR03DA025850 · NIDA · TORREY PINES INST FOR MOLECULAR STUDIES · PI NEFZI, ADEL · 2009 to 2010
$450k
NIDA NIH HHS R03 DA025850NIGMS NIH HHS P41 GM079590NIGMS NIH HHS P41 GM081261
6 · The paper itself

Abstract

Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in high purities and good overall yields.

Identifiers

PMID21113437
PMCPMC2989683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.