Evidence map›Paper›PMID 21113422›Full record

ReviewTherapeutic delivery2010

Stem cells and regenerative medicine: accomplishments to date and future promise.

Karim Y Helmy, Shyam A Patel, Kimberly Silverio, Lillian Pliner, Pranela Rameshwar

Abstract readReview
In one paragraph

Review in Therapeutic delivery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Synthetic alternatives to Matrigel.Nature reviews. Materials · 2020
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. TJournal of cancer stem cell research · 2014
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karim Y HelmyDepartment of Medicine-Division of Hematology/Oncology, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, 185 South Orange Ave, Newark, NJ 07103, USA.
Shyam A Patel
Kimberly Silverio
Lillian Pliner
Pranela Rameshwar

Funding

BREAST CANCER/BONE MARROW STROMAL INTERACTIONSR01CA089868 · NCI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI RAMESHWAR, PRANELA · 2000 to 2003
$873k
NCI NIH HHS R01 CA089868
6 · The paper itself

Abstract

More than 50 years have passed since the first allogeneic hematopoietic stem cell transplant in patients; however, the promise of other stem cell populations for tissue replacement and repair remains unachieved. When considering cell-based interventions for personalized medicine, the factors influencing therapeutic success and safety are more complicated than for traditional small-molecule pharmacological agents and protein biologics. Failure to progress personalized stem cell therapies to the clinic has resulted from complications that include an incomplete understanding of developmental programs and the diversity of host-donor interactions. In order to more rapidly extend the use of stem cells to the clinic, a better understanding of the different stem cell sources and the implications of their host interactions is required. In this review, we introduce the currently available sources and highlight recent literature that instructs the potential and limitations of their use.

Indexed as

Regenerative MedicineStem Cell TransplantationAdult Stem CellsHumansMesenchymal Stem Cell Transplantation

Identifiers

PMID21113422
PMCPMC2990533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.