ArticleGenes & cancer2010
Myc, mondo, and metabolism.
Article in Genes & cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction.GeroScience · 2024Article
- Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells.Scientific reports · 2019Article
- FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection.Physiological reports · 2019Article
- The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis.Frontiers of medicine · 2018Review
- Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance.International journal of molecular sciences · 2017Review
- Review
- Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations.PeerJ · 2017Article
- Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine.Angewandte Chemie (International ed. in English) · 2016Article
- MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.The Journal of clinical investigation · 2016Article
- Tissue Specific Effects of Dietary Carbohydrates and Obesity on ChREBPα and ChREBPβ Expression.Lipids · 2016Article
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- Article
- Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.Cancer cell · 2015Article
- Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition.Physical biology · 2014Article
- c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation.Neuroscience · 2014Article
- The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.PLoS genetics · 2014Article
- Stress-induced cleavage of Myc promotes cancer cell survival.Genes & development · 2014Article
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks.Cold Spring Harbor perspectives in medicine · 2013Review
- Unlocking the mysterious mechanisms of Myc.Nature medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Myc family of proto-oncogenes plays a central role in tumorigenesis, yet identifying the specific transcriptional targets required for its oncogenic function remains a challenge. Given Myc's broad role in transcriptional regulation, it seems unlikely that there exists one or even a small set of Myc effectors strictly required for transformation. Over the last decade or so, it has become clear that Myc can drive several metabolic pathways associated with cell growth. There is compelling evidence that Myc regulates these pathways directly and that their regulation is not an epiphenomenon. As such, for understanding Myc's pleiotropic role in cell growth, cell division, and cell death, it may be fruitful to focus more broadly on Myc-regulated pathways than on specific targets. Myc was first shown to regulate glycolysis, but it is now clear that Myc regulates many biosynthetic pathways required for cell growth and division. A related family of transcriptional regulators, the Mondo family, has recently been discovered that may interact with members of the Myc family to control cell growth. The Mondo family is a key sensor of intracellular bioenergetic charge, and one function appears to be in controlling the availability and utilization of intracellular glucose. Here we focus on the metabolic pathways regulated by Myc and Mondo and speculate on the largely unexplored question of their cooperation in controlling cancer cell metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.