ReviewProtein & cell2010
Apoptotic regulation and tRNA.
Review in Protein & cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives.International journal of molecular sciences · 2025Review
- Codon adaptation by synonymous mutations impacts the functional properties of the estrogen receptor-alpha protein in breast cancer cells.Molecular oncology · 2023Article
- Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA.Current medicinal chemistry · 2023Article
- tRNA Function and Dysregulation in Cancer.Frontiers in cell and developmental biology · 2022Review
- Dynamics of intracellular stress-induced tRNA trafficking.Nucleic acids research · 2019Article
- A genetically encoded fluorescent tRNA is active in live-cell protein synthesis.Nucleic acids research · 2017Article
- miR-590-5P inhibits the progression of tongue squamous cell carcinoma by targeting FasL.International journal of clinical and experimental pathology · 2017Article
- Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction.The Journal of biological chemistry · 2016Article
- RNA fragments mimicking tRNA analogs interact with cytochrome c.Molecular biology reports · 2016Article
- Multiple Layers of Stress-Induced Regulation in tRNA Biology.Life (Basel, Switzerland) · 2016Review
- Circulating small non-coding RNA signature in head and neck squamous cell carcinoma.Oncotarget · 2015Article
- Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping.ACS chemical biology · 2014Article
- Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress.Molecular and cellular biology · 2014Article
- Transfer RNA and human disease.Frontiers in genetics · 2014Review
- Cellular mechanisms controlling caspase activation and function.Cold Spring Harbor perspectives in biology · 2013Review
- Kinetics of tRNA folding monitored by aminoacylation.RNA (New York, N.Y.) · 2012Article
- The Effect of Dysregulation of tRNA Genes and Translation Efficiency Mutations in Cancer and Neurodegeneration.Frontiers in genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Apoptotic regulation is critical to organismal homeostasis and protection against many human disease processes such as cancer. Significant research efforts over the past several decades have illuminated many signaling molecules and effecter proteins responsible for this form of programmed cell death. Recent evidence suggests that transfer RNA (tRNA) regulates apoptotic sensitivity at the level of cytochrome c-mediated apoptosome formation. This finding unexpectedly places tRNA at the nexus of cellular biosynthesis and survival. Here we review the current understanding of both the apoptotic machinery and tRNA biology. We describe the evidence linking tRNA and cytochrome c in depth, and speculate on the implications of this link in cell biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.