ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2010
A New Method for Measuring the Dynamic Shape Change of Platelets.
Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- DNA Origami-Platelet Adducts: Nanoconstruct Binding without Platelet Activation.Bioconjugate chemistry · 2022Article
- A predictive multiscale model for simulating flow-induced platelet activation: Correlating in silico results with in vitro results.Journal of biomechanics · 2021Article
- A phenomenological particle-based platelet model for simulating filopodia formation during early activation.International journal for numerical methods in biomedical engineering · 2015Article
- The role of fibrinogen spacing and patch size on platelet adhesion under flow.Acta biomaterialia · 2012Article
- Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet shape change is a dynamic process that has been classified in different types. Exact documentation of platelet structure needs an improved method of measuring platelet shape.
methods10 μl of platelet-rich plasma (PRP) from anticoagulated whole blood (3.2% buffered sodium citrate 0.105 mol/l) was put onto a glass slide covered with a cover slip. By use a of dark field light microscope connected with a CMOS-Camera a photographic snap-shot was taken after 5 and 30 min. Diameter of platelets and length of filopodia were measured with a self-developed plugin for ImageJ software. Statistic calculation was performed with Excel WinSTAT Microsoft software.
resultsWe showed a swelling of the granulomer from 2.06 ± 0.56 μm to 2.33 ± 0.59 μm (p < 0.05), a reduction of pseudopodia (2.10 ± 0.94 vs. 1.78 ± 1.04 μm; p < 0.05) in conjunction with an increase of hyalomer diameter from 3.29 ± 0.83 to 3.50 ± 0.85 μm (p < 0.05), and an increase of pseudopodia length from 2.68 ± 1.45 μm to 3.67 ± 1.79 μm (p < 0.005) in conjunction with an increase of hyalomer diameter from 6.58 ± 1.91 μm to 7.94 ± 1.87 μm (p < 0.05).
conclusionWe revealed and documented a dynamic change of platelet size and filopodia structure in PRP. This method allows an exact analysis of platelet size and surface structures.
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Registered trials
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